The focus of my laboratory is to understand the genomic basis of tumor development and progression. We use both large-scale genomic analyses and functional dissection to elucidate the drivers of oncogenesis. Using this information, we seek to develop improved diagnostic and therapeutic modalities for human cancers.

Publications

Veeriah S, Taylor BS, Meng S, Fang F, Yilmaz E, Vivanco I, Janakiraman M, Schultz N, Hanrahan AJ, Pao W, Ladanyi M, Sander C, Heguy A, Holland EC, Paty PB, Mischel PS, Liau L, Cloughesy TF, Mellinghoff IK, Solit DB, Chan TA. Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat Genet. 2010 Jan;42(1):77-82. doi: 10.1038/ng.491. Epub 2009 Nov 29.

Fang F, Turcan S, Rimner A, Kaufman A, Giri D, Morris LG, Shen R, Seshan V, Mo Q, Heguy A, Baylin SB, Ahuja N, Viale A, Massague J, Norton L, Vahdat LT, Moynahan ME, Chan TA. Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci Transl Med. 2011 Mar 23;3(75):75ra25. doi: 10.1126/scitranslmed.3001875.

Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AW, Lu C, Ward PS, Thompson CB, Kaufman A, Guryanova O, Levine R, Heguy A, Viale A, Morris LG, Huse JT, Mellinghoff IK, Chan TA. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012 Feb 15;483(7390):479-83. doi: 10.1038/nature10866.

Morris LG, Kaufman AM, Gong Y, Ramaswami D, Walsh LA, Turcan Ş, Eng S, Kannan K, Zou Y, Peng L, Banuchi VE, Paty P, Zeng Z, Vakiani E, Solit D, Singh B, Ganly I, Liau L, Cloughesy TC, Mischel PS, Mellinghoff IK, Chan TA. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet. 2013 Mar;45(3):253-61. doi: 10.1038/ng.2538. Epub 2013 Jan 27. [PMID:23354438]

Ho AS, Kannan K, Roy DM, Morris LGT, Ganly I, Katabi N, Ramaswami D, Walsh LA, Eng, Stephanie, Huse JT, Zhang J, Dolgalev I, Huberman K, Heguy A, Viale A, Drobnjak M, Leversha MA, Rice CE, Singh B, Iyer NG, Leemans CR, Bloemena E, Ferris RL, Seethala RR, Gross BE, Liang Y, Sinha R, Peng L, Raphael BJ, Turcan S, Gong Y, Schultz N, Kim S, Chiosea S, Shah JP, Sander C, Lee W, Chan TA* (*corresponding author). The mutational landscape of adenoid cystic carcinoma. Nat Genet. 2013 May 19;45(7):791-8. doi: 10.1038/ng.2643. Epub 2013 May 19.

Office phone:
212-639-8904 (For patient-related issues); 646-888-2765 (For non-clinical issues only)
Laboratory phone:
646-888-2783
E-mail:
chant@mskcc.org
Selected Achievements

Era of Hope Scholar, Department of Defense (2012)

Frederick R. Adler Chair for Junior Faculty, Memorial Sloan Kettering Cancer Center (2012)

Member, American Society of Clinical Investigation (2012)

Distinguished Scientist Award, Sontag Foundation (2010)

Han-Mo Koo Memorial Lectureship Award, Van Andel Institute (2010)

Clinical Scientist Development Award, Doris Duke Charitable Foundation (2009)

Scholar Award, Flight Attendant Medical Research Institute (2008)

Louis V. Gerstner Investigator Award, Memorial Sloan Kettering Cancer Center (2008)