The suprachiasmatic nucleus (SCN) is the home of the mammalian clock. This tissue, which exhibits a daily cycle of PSA expression, not only sends clock information to many different tissues, but also adjusts the clock with respect to changes in light and activity. Studies from our group have shown that PSA has a fundamental role in the plasticity required for clock adjustments.
Our current projects are designed to determine the nature of the cell interactions in the SCN that are being affected by PSA. As little is known about the cellular events underlying SCN function, these studies will be valuable to the field of circadian biology as well as to further understanding PSA function.