Urs Stephen Rutishauser: Response to Stress and Pain

We have proposed that the expression of PSA in nervous system regions that process inputs from chronic insults, such as pain and stress, provides in effect a “circuit breaker” that limits damage caused by these inputs. This work focuses in the dorsal spinal column, known to undergo structural plasticity in response to pain, and the hippocampus/amygdala system that responds to stress. Present studies are attempting to show that in these systems, PSDA is promoting the temporary disengagement of synaptic connections.