The laboratory investigates programmed cell death, a cellular process functioning to maintain tissue homeostasis and eliminate damaged or unwanted cells in multicellular organism. Programmed cell death plays crucial roles in development, immune responses, and many other physiological events. Malfunction of programmed cell death can lead to diseases such as cancer, immune disorders, and neurodegenerative diseases. We employ multiple approaches to study the molecular basis of programmed cell death. We also seek to translate our basic research findings into novel cancer therapies.