Ying-Xian Pan: Selected Publications

Majumdar, S., Grinnell, S., Le Rouzic, V., Burgman, M., Polikar, L., Ansonoff, M., Pintar, J., Pan, Y.-X., Pasternak, G.W. Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects (2011) Proceedings of the National Academy of Sciences of the United States of America, 108 (49), pp. 19778-19783.

Lefave, C.V., Squatrito, M., Vorlova, S., Rocco, G.L., Brennan, C.W., Holland, E.C., Pan, Y.-X., Cartegni, L.Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas (2011) EMBO Journal, 30 (19), pp. 4084-4097.

Pasternak, G., Pan, Y.-X.Mu opioid receptors in pain management(2011) Acta Anaesthesiologica Taiwanica, 49 (1), pp. 21-25.

Pasternak, G.W., Pan, Y.-X. Mix and Match: Heterodimers and Opioid Tolerance(2011) Neuron, 69 (1), pp. 6-8.

Pan, Y.-X., Pasternak, G.W. Molecular Biology of Mu Opioid Receptors, pp121-160, The Opiate Receptors, ed: Pasternak, G.W., Humana PressIsbn: 978-1-60761-993-2

Xu, J., Xu, M., Rossi, G.C., Pasternak, G.W., Pan, Y.-X. Identification and characterization ofseven new exon 11-associated splice variants of the rat mopioid receptor gene, OPRM1 (2011) Molecular Pain, 7, art. no. 9,

Kolesnikov, Y.A., Chereshnev, I., Criesta, M., Pan, Y.-X., Pasternak, G.W. Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice (2009) Brain Research, 1289, pp. 14-21. 

Hadjimarkou, M.M., Abbadie, C., Kasselman, L.J., Pan, Y.-X., Pasternak, G.W., Bodnar, R.J. Changes in mouse mu opioid receptor exon 7/8-like immunoreactivity following food restriction and food deprivation in rats (2009) Synapse, 63 (7), pp. 585-597. 

Pan, Y.-X., Xu, J., Xu, M., Rossi, G.C., Matulonis, J.E., Pasternak, G.W. Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions (2009) Proceedings of the National Academy of Sciences of the United States of America, 106 (12), pp. 4917-4922. 

Xu, J., Xu, M., Hurd, Y.L., Pasternak, G.W., Pan, Y.-X. Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene (2009) Journal of Neurochemistry, 108 (4), pp. 962-972.

Xu, J., Xu, M., Pan, Y.-X. Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic mice (2006) BMC Molecular Biology, 7, art. no. 41,

Zhang, Y., Pan, Y.-X., Kolesnikov, Y., Pasternak, G.W. Immunohistochemical labeling of the mu opioid receptor carboxy terminal splice variant mMOR-1B4 in the mouse central nervous system (2006) Brain Research, 1099 (1), pp. 33-43.

Pan, Y.-X. Diversity and complexity of the mu opioid receptor gene: Alternative pre-mRNA splicing and promoters (2005) DNA and Cell Biology, 24 (11), pp. 736-750.

Pan, Y.-X., Xu, J., Bolan, E., Moskowitz, H.S., Xu, M., Pasternak, G.W. Identification of four novel exon 5 splice variants of the mouse μ-opioid receptor gene: Functional consequences of C-terminal splicing (2005) Molecular Pharmacology, 68 (3), pp. 866-875. 

Israel, Y., Kandov, Y., Khaimova, E., Kest, A., Lewis, S.R., Pasternak, G.W., Pan, Y.X., Rossi, G.C., Bodnar, R.J. NPY-induced feeding: Pharmacological characterization using selective opioid antagonists and antisense probes in rats (2005) Peptides, 26 (7), pp. 1167-1175.

Pan, L., Xu, J., Yu, R., Xu, M.-M., Pan, Y.-X., Pasternak, G.W. Identification and characterization of six new alternatively spliced variants of the human μ opioid receptor gene, OPRM (2005) Neuroscience, 133 (1), pp. 209-220.

Hadjimarkou, M.M., Singh, A., Kandov, Y., Israel, Y., Pan, Y.-X., Rossi, G.C., Pasternak, G.W., Bodnar, R.J. Opioid receptor involvement in food deprivation-induced feeding: Evaluation of selective antagonist and antisense oligodeoxynucleotide probe effects in mice and rats (2004) Journal of Pharmacology and Experimental Therapeutics, 311 (3), pp. 1188-1202. 

Pasternak, D.A., Pan, L., Xu, J., Yu, R., Xu, M.-M., Pasternak, G.W., Pan, Y.-X. Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: Dissociation of affinity and efficacy (2004) Journal of Neurochemistry, 91 (4), pp. 881-890.

Abbadie, C., Pan, Y.-X., Pasternak, G.W. Immunohistochemical study of the expression of EXON11-containing μ opioid receptor variants in mouse brain (2004) Neuroscience, 127 (2), pp. 419-430.

Bolan, E.A., Pan, Y.-X., Pasternak, G.W. Functional Analysis of MOR-1 Splice Variants of the Mouse mu Opioid Receptor Gene Oprm (2004) Synapse, 51 (1), pp. 11-18.

Hadjimarkou, M.M., Khaimova, E., Pan, Y.-X., Rossi, G.C., Pasternak, G.W., Bodnar, R.J. Feeding induced by food deprivation is differentially reduced by opioid receptor antisense oligodeoxynucleotide probes in rats (2003) Brain Research, 987 (2), pp. 223-232.

Pan, Y.X. Expression of opioid receptors in mammalian cell lines. (2003) Methods in molecular medicine, 84, pp. 17-28.

Pan, Y.X. Identification of alternatively spliced variants from opioid receptor genes. (2003) Methods in molecular medicine, 84, pp. 65-75.

Pan, Y.X. Molecular cloning of opioid receptors by cDNA library screening. (2003) Methods in molecular medicine, 84, pp. 3-16. 

Pan, Y.-X., Xu, J., Mahurter, L., Xu, M., Gilbert, A.-K., Pasternak, G.W. Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X (2003) Biochemical and Biophysical Research Communications, 301 (4), pp. 1057-1061. 

Pan, Y.-X., Bolan, E., Pasternak, G.W. Dimerization of morphine and orphanin FQ/nociceptin receptors: Generation of a novel opioid receptor subtype (2002) Biochemical and Biophysical Research Communications, 297 (3), pp. 659-663.

Pan, Y.-X. Identification and characterization of a novel promoter of the mouse mu opioid receptor gene (Oprm) that generates eight splice variants (2002) Gene, 295 (1), pp. 97-108.

Pan, Y.-X., Xu, J., Mahurter, L., Bolan, E., Xu, M., Pasternak, G.W. Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (24), pp. 14084-14089

Abbadie, C., Pan, Y.-X., Drake, C.T., Pasternak, G.W. Comparative immunohistochemical distributions of carboxy terminus epitopes from the mu-opioid receptor splice variants MOR-1D, MOR-1 and MOR-1C in the mouse and rat CNS (2000) Neuroscience, 100 (1), pp. 141-153.

Abbadie, C., Pan, Y.-X., Pasternak, G.W. Differential distribution in rat brain of mu opioid receptor carboxy terminal splice variants MOR-1C-like and MOR-1-like immunoreactivity: Evidence for region-specific processing (2000) Journal of Comparative Neurology, 419 (2), pp. 244-256. 

Pan, Y.-X., Xu, J., Bolan, E., Chang, A., Mahurter, L., Rossi, G., Pasternak, G.W. Isolation and expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F (2000) FEBS Letters, 466 (2-3), pp. 337-340. 

Pasternak, G.W., Pan, Y.-X. Antisense mapping: Assessing functional significance of genes and splice variants (1999) Methods in Enzymology, 314, pp. 51-60.

Pan, Y.-X., Xu, J., Bolan, E., Abbadie, C., Chang, A., Zuckerman, A., Rossi, G., Pasternak, G.W. Identification and characterization of three new alternatively spliced μ-opioid receptor isoforms (1999) Molecular Pharmacology, 56 (2), pp. 396-403.

Schuller, A.G.P., King, M.A., Zhang, J., Bolan, E., Pan, Y.-X, Morgan, D.J., Chang, A., Czick, M.E., Unterwald, E.M., Pasternak, G.W., Pintar, J.E. Retention of heroin and morphine-6β-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1 (1999) Nature Neuroscience, 2 (2), pp. 151-156. 

Hom, J.S.H., Goldberg, I., Mathis, J., Pan, Y.-X., Brooks, A.I., Ryan-Moro, J., Scheinberg, D.A., Pasternak, G.W. [125I]Orphanin FQ/nociceptin binding in Raji cells (1999) Synapse, 34 (3), pp. 187-191.

Pan, Y.-X., Xu, J., Wan, B.-L., Zuckerman, A., Pasternak, G.W. Identification and differential regional expression of KOR-3/ORL-1 gene splice variants in mouse brain (1998) FEBS Letters, 435 (1), pp. 65-68.

Pan, Y.-X., Mei, J., Xu, J., Wan, B.-L., Zuckerman, A., Pasternak, G.W. Cloning and characterization of a mouse σ1 receptor (1998) Journal of Neurochemistry, 70 (6), pp. 2279-2285.

Burdick, K., Yu, W.-Z., Ragnauth, A., Moroz, M., Pan, Y.X., Rossi, G.C., Pasternak, G.W., Bodnar, R.J. Antisense mapping of opioid receptor clones: Effects upon 2-deoxy-D- glucose-induced hyperphagia (1998) Brain Research, 794 (2), pp. 359-363.

Kolesnikov, Y.A., Pan, Y.-X., Babey, A.-M., Jain, S., Wilson, R., Pasternak, G.W. Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: Evidence for opposing NO actions on morphine analgesia and tolerance (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (15), pp. 8220-8225.

King, M., Pan, Y.-X., Mei, J., Chang, A., Xu, J., Pasternak, G.W. Enhanced κ-opioid receptor-mediated analgesia by antisense targeting the σ1 receptor (1997) European Journal of Pharmacology, 331 (1), pp. R5-R6.

Rossi, G.C., Leventhal, L., Pan, Y.-X., Cole, J., Su, W., Bodnar, R.J., Pasternak, G.W. Antisense mapping of MOR-1 in rats: Distinguishing between morphine and morphine-6β-glucuronide antinociception (1997) Journal of Pharmacology and Experimental Therapeutics, 281 (1), pp. 109-114.

Chien, C.-C., Carroll, F.I., Brown, G.P., Pan, Y.-X., Bowen, W., Pasternak, G.W. Synthesis and characterization of [125I]3'-(-)-iodopentazocine, a selective σ1 receptor ligand (1997) European Journal of Pharmacology, 321 (3), pp. 361-368.

Pan, Y.-X., Xu, J., Ryan-Moro, J., Mathis, J., Hom, J.S.H., Jianfeng, M., Pasternak, G.W. Dissociation of affinity and efficacy in KOR-3 chimeras (1996) FEBS Letters, 395 (2-3), pp. 207-210.

Pan, Y.-X., Xu, J., Pasternak, G.W. Structure and characterization of the gene encoding a mouse kappa3-related opioid receptor (1996) Gene, 171 (2), pp. 255-260.

Leventhal, L., Cole, J.L., Rossi, G.C., Pan, Y.X., Pasternak, G.W., Bodnar, R.J. Antisense oligodeoxynucleotides against the MOR-1 clone alter weight and ingestive responses in rats (1996) Brain Research, 719 (1-2), pp. 78-84.

Pan, Y.-X., Xu, J., Pasternak, G.W. Cloning and expression of a cDNA encoding a mouse brain orphanin FQ/nociceptin precursor (1996) Biochemical Journal, 315 (1), pp. 11-13.

Pasternak, G.W., Pan, Y.-X., Cheng, J. Correlating the pharmacology and molecular biology of opioid receptors. Cloning and antisense mapping a kappa3-related opiate receptor (1995) Annals of the New York Academy of Sciences, 757, pp. 332-338.

Rossi, G.C., Pan, Y.-X., Brown, G.P., Pasternak, G.W. Antisense mapping the MOR-1 opioid receptor: Evidence for alternative splicing and a novel morphine-6β-glucuronide receptor (1995) FEBS Letters, 369 (2-3), pp. 192-196.

Standifer, K.M., Jenab, S., Su, W., Chien, C.-C., Pan, Y.-X., Inturrisi, C.E., Pasternak, G.W. Antisense oligodeoxynucleotides to the cloned δ receptor DOR-1: Uptake, stability, and regulation of gene expression (1995) Journal of Neurochemistry, 65 (5), pp. 1981-1987.

Pan, Y.-X., Cheng, J., Xu, J., Rossi, G., Jacobson, E., Ryan-Moro, J., Brooks, A.I., Dean, G.E., Standifer, K.M., Pasternak, G.W. Cloning and functional characterization through antisense mapping of a κ3-related opioid receptor (1995) Molecular Pharmacology, 47 (6), pp. 1180-1188.

Pan, Y.X., Cheng, J., Xu, J., Pasternak, G.W. Cloning, expression and classification of a kappa3-related opioid receptor using antisense oligodeoxynucleotides (1994) Regulatory Peptides, 54 (1), pp. 217-218.

Chien, C.-C., Brown, G., Pan, Y.-X., Pasternak, G.W. Blockade of U50,488H analgesia by antisense oligodeoxynucleotides to a κ-opioid receptor (1994) European Journal of Pharmacology, 253 (3), pp. R7-R8.

Rossi, G., Pan, Y.-X., Cheng, J., Pasternak, G.W. Blockade of morphine analgesia by an antisense oligodeoxynucleotide against the mu receptor (1994) Life Sciences, 54 (21), pp. 375-379.

Pan, Y.-X., Gu, H.H., Xu, J., Dean, G.E. Saccharomyces cerevisiae expression of exogenous vacuolar ATPase subunits B (1993) Biochimica et Biophysica Acta - Biomembranes, 1151 (2), pp. 175-185.

Pan, Y.-X., Xu, J., Strasser, J.E., Howell, M., Dean, G.E. Structure and expression of subunit A from the bovine chromaffin cell vacuolar ATPase (1991) FEBS Letters, 293 (1-2), pp. 89-92.