The main interests of my laboratory are to elucidate the mechanism of γ-secretase-dependent Notch signaling and amyloid precursor protein (APP) processing under physiological and pathological conditions and to develop target-based therapies.(1) γ-Secretase represents a novel class of proteases that catalyze proteolysis of substrates within the transmembrane domain,(2)(3) an apparently hydrophobic environment, wherein water is required for peptide hydrolysis. Intramembranous proteases, including γ-secretase, site 2 proteases, rhomboids and signal peptide peptidase, play an essential role in many biological processes ranging from sterol regulation to development.(2)(3) Unraveling the intricacies of these enigmatic proteases is a formidable challenge that requires novel insights and approaches.


  1. Selkoe, D. J., and Wolfe, M. S. (2007) Cell 131, 215-221
  2. Brown, M. S., Ye, J., Rawson, R. B., and Goldstein, J. L. (2000) Cell 100, 391-398
  3. Erez, E., Fass, D., and Bibi, E. (2009) Nature 459, 371-378
Office phone:
646-888-2194 or 2193
Office fax:
Laboratory phone:
646-888-2204 or 2531
Yueming Li

At Work: Biochemist Yueming Li

Yueming Li aims to develop new agents that inhibit particular intramembrane proteases associated with cancer.