While I have broad experience in treating all leukemias, over the past 20 years I have also acquired expertise in several rare hematologic malignancies; including hairy cell leukemia, large granular lymphocyte leukemia, hypereosinophilic syndromes, mastocytosis, and histiocytic diseases such as Langerhans cell histiocytosis (in adults), sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease), and Erdheim-Chester disease. I provide state-of-the-art diagnosis and treatment for these uncommon diseases, and through clinical and laboratory studies I am working to develop new therapies for them.
As an active translational investigator I have had a long-standing interest in growth factors that affect the growth of bone marrow and leukemia cells. More recently, I have focused on metabolic differences between normal and leukemic cells. My colleagues and I believe that these differences can be exploited to discover new drugs that preferentially target cancer cells.