Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma (NHL) that can be challenging to treat. One approach is to combine an antibody against the tumor with a chemotherapy drug. In this study, researchers are evaluating the used of the antibody ofatumumab and the chemotherapy drug bendamustine for patients with previously untreated MCL who cannot have an autologous stem cell transplant.
Ofatumumab is approved for treating chronic lymphocytic leukemia (CLL). Bendamustine is approved for treating CLL and slow-growing NHL. Their use in this study is considered investigational. Patients will receive ofatumumab alone or with bendamustine, depending upon their initial risk profile.