Older individuals are more likely to experience side effects from chemotherapy which may impair the effectiveness of treatment. Most people with non-Hodgkin lymphoma (NHL) are age 60 or older, putting them at increased risk of chemotherapy side effects. In this study, researchers want to learn which older patients are more likely to have side effects. Patients will complete a questionnaire and take a short walking test (measuring how quickly they get up from a chair and walk ten feet) before each cycle of chemotherapy. Researchers will compare the results of the questionnaire and walking test with each patient’s experience with side effects.
In a second part of the study, patients with a type of NHL called diffuse large B-cell lymphoma (DLBCL) may receive two drugs before their chemotherapy — prednisone and rituximab — which may help lower the side effects of chemotherapy. These patients will then answer the questionnaire and take the same walking test before receiving chemotherapy.