Pomalidomide is an anticancer drug that modulates immune cells and inhibits the growth of the blood vessels that cancers need to grow and spread. When given with dexamethasone, pomalidomide helps to kill cancer cells.
In this study, researchers want to find the highest dose of pomalidomide that can be given safely with dexamethasone to patients with primary central nervous system lymphoma (PCNSL) or primary vitreoretinal lymphoma (PVRL) that has come back after therapy or has continued to grow despite other treatments. Pomalidomide has shown activity against lymphoma in laboratory studies and penetrates well into the brain, making it a promising drug to treat PCNSL and PVRL.
Pomalidomide is approved for the treatment of a bone marrow cancer called multiple myeloma, but its use in this study is investigational. It is a capsule that is taken orally (by mouth).