Within Memorial Hospital, many scientists lead research laboratories, including some physician-scientists who apply insights from the clinic to their laboratory work. Our investigators conduct research ranging from analyzing genetic changes in patient tumor samples to developing new imaging techniques to studying the best ways to optimize radiation therapy delivery.
Learn more about our investigators who head basic and translational research laboratories within Memorial Hospital.
Omar I. Abdel-Wahab
Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.
Cristina R. Antonescu
Physician-scientist Cristina Antonescu studies the molecular pathogenesis of soft tissue sarcomas and gastrointestinal stromal tumors.
Scott A. Armstrong
Physician-scientist Scott Armstrong focuses on defining genetic and epigenetic programs that control the extensive self-renewal properties associated with leukemia and other cancers.
Memorial Sloan-Kettering Physician-in-Chief José Baselga studies mechanisms of resistance to targeted therapies and identification of novel therapeutic combinations in solid cancers.
Michael F. Berger
Researcher Michael Berger focuses on massively parallel sequencing of tumor DNA for biomarker discovery and clinical diagnostics.
Michelle S. Bradbury
Clinician-scientist Michelle Bradbury develops translational, tumor-targeting, PET-optical silica nanoparticle probes for diagnostics, drug delivery, and sensing.
Cameron W. Brennan
Physician-scientist Cameron Brennan focuses on genomic analysis of human and mouse gliomas and medulloblastomas.
Renier J. Brentjens
Physician-scientist Renier Brentjens develops novel immunotherapies for leukemias and lymphomas.
Physician-scientist Jacqueline Bromberg focues on aberrantly activated Stat3 and the mechanisms of Stat3-mediated transformation.
Jorge A. Carrasquillo
Physician-scientist Jorge Carrasquillo focuses on the development of targeted radioimmunotherapy drugs.
Brett S. Carver
Physician-scientist Brett Carver focuses on the identification of molecular pathways involved in prostate cancer initiation and progression.
Timothy A. Chan
Physician-scientist Timothy Chan focuses on the identification and characterization of tumor suppressors in glioblastoma and breast cancer.
Physician-scientist Sarat Chandarlapaty studies the regulation of growth factor signaling networks in cancer.
Physician-scientist Yu Chen studies the role of transcription factors that are critical for prostate cancer development.
Emily H. Cheng
Physician-scientist Emily Cheng focuses on the molecular mechanisms of cell death and their implications in tumorigenesis and cancer therapy, with primary emphasis on lung and kidney cancers.
Nai-Kong V. Cheung
Physician-scientist Nai-Kong Cheung focuses on engineering of antibodies and immune cells to treat solid tumors in children.
Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic transcription factors in GIST and other solid tumors.
Amita Shukla Dave
Medical physicist Amita Shukla Dave is developing a program in multimodality imaging for head and neck cancer and developing new imaging criteria for prostate cancer.
Joseph O. Deasy
Medical Physics Department Chair Joseph Deasy focuses on integration and analysis of dose, imaging, and molecular data to predict outcomes and guide personalized treatments.
Physician-scientist Ronald DeMatteo focuses on strategies to reduce immune subversion in gastrointestinal stromal tumor and liver cancer and on immunobiology in liver cancer.
Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.
James A. Fagin
Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.
Physician-scientist Yuman Fong develops herpes-based oncolytic viral therapies for the treatment of malignancy.
Alan M. Hanash
Physician-scientist Alan Hanash studies transplant immunology and immune-mediated mechanisms of tissue damage and regeneration.
James J. Hsieh
Physician-scientist James Hsieh focuses on developing novel therapeutics targeting cancer cell proliferation; he also directs Memorial Sloan-Kettering’s translational kidney cancer research program.
Katharine C. Hsu
Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.
John L. Humm
Medical physicist John Humm focuses on noninvasive imaging of the tumor microenvironment using nuclear imaging methods.
Jason T. Huse
Physician-scientist Jason Huse focuses on the molecular pathogenesis of brain tumors, particularly high-grade gliomas.
Medical physicist Andrew Jackson studies the relationship between radiotherapy dose distributions and treatment outcome and the optimization of radiotherapy treatment planning.
Kayvan R. Keshari
Biochemist and imaging specialist Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer targets.
Tari A. King
Physician-scientist Tari King studies the molecular genetics of high-risk breast lesions and the transition from in situ to invasive breast carcinoma.
Moritz F. Kircher
Physician-scientist Moritz Kircher develops novel molecular imaging approaches with a focus on surface-enhanced Raman spectroscopy and magnetic resonance imaging.
Jason A. Koutcher
Physician-scientist Jason Koutcher studies applications of magnetic resonance spectroscopy and imaging to enhance the therapeutic gain of different antineoplastic modalities.
Molecular pathologist Marc Ladanyi studies the molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.
Douglas A. Levine
Physician-scientist Douglas Levine studies the genomic basis for prevention and control of ovarian and uterine carcinomas.
Ross L. Levine
Physician-scientist Ross Levine focuses on the investigation of genetic basis of hematopoietic malignancies.
Jason S. Lewis
Radiochemist Jason Lewis develops radiopharmaceuticals for the imaging and therapy of cancer.
Gloria C. Li
Radiation scientist Gloria Li studies the response of cells to stressors such as heat and radiation.
Gikas S. Mageras
Medical physicist Gikas Mageras focuses on radiation treatment planning and verification using CT images to guide radiation treatment and monitor and correct for patient internal and external movement during treatment delivery.
Babak J. Mehrara
Physician-scientist Babak Mehrara studies the regulation of lymphatic regeneration after surgery and development of lymphedema.
Ingo K. Mellinghoff
Physician-scientist Ingo Mellinghoff studies signal transduction alterations in primary brain tumors.
Cancer geneticist Kenneth Offit focuses on gene characterization; genetic and epidemiologic studies of cancer-predisposing alleles; and the therapeutic, prognostic, and psychosocial translation of these findings.
Physician-scientst Ying-Xian Pan studies the transcription regulation and function of opioid receptor genes.
Christopher Y. Park
Physician-scientist Christopher Park focuses on the identification and characterization of molecular pathways that regulate normal and malignant stem cells in the hematopoietic system.
Physician-scientist Vladimir Ponomarev focuses on developing reporter genetic systems for specific applications such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.
Physician-scientist Govind Ragupathi studies tumor vaccinology, including approaches to augmenting the antibody and T cell response to defined cancer antigens.
Optical engineer Milind Rajadhyaksha studies confocal microscopy for the imaging of cancer, technology development, and translational and clinical studies in skin and head and neck cancers.
Shyam S. Rao
Physician-scientist Shyam Rao studies the role of the tumor microenvironment in tumorigenesis and response to radiation therapy.
Imaging specialist Thomas Reiner focuses on the development of novel imaging probes for both PET imaging and optical imaging technologies.
Jorge S. Reis-Filho
Physician-scientist Jorge Reis-Filho focuses on the development of a predictive molecular classification for rare types of breast cancer and characterization of intratumor genetic heterogeneity in breast cancers.
Charles M. Rudin
Physician-scientist Charles Rudin focuses on the development and testing of novel therapeutic approaches to lung cancer in preclinical models.
Charles L. Sawyers
Human Oncology and Pathogenesis Program Chair Charles Sawyers develops molecularly targeted cancer therapy.
Physician-scientist Gary Schwartz focuses on the identification of cell-cycle inhibitors that promote chemotherapy-induced apoptosis and their use in cancer therapy.
Physician-scientist Samuel Singer studies the genomic alterations that define new targets for therapy in sarcoma.
Physician-scientist Bhuvanesh Singh focuses on delineating the role of ubiquitination in cancer pathogenesis.
David B. Solit
Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
David R. Spriggs
Physician-scientist David Spriggs studies the molecular mechanisms of drug resistance in ovarian cancer.
Physician-scientist Viviane Tabar focuses on in vivo applications of neural derivatives of pluripotent stem cells (such as iPS and ES cells) and on cancer stem cells in human brain tumors.
Laura H. Tang
Physician-scientist Laura Tang studies the molecular pathogenesis of cell transformation in neuroendocrine neoplasms of the gastrointestinal tract and pancreas and adenocarcinomas of the stomach and gastrointestinal junction.
Sunitha B. Thakur
Medical physicist Sunitha Thakur focuses on MR biomarkers for early detection and monitoring response to treatment.
Wolfgang A. Weber
Physician-scientist Wolfgang Weber specializes in imaging and therapy, with a focus on the translation of novel drugs, imaging agents, and methodologies from bench to bedside.
Martin R. Weiser
Physician-scientist Martin Weiser investigates the mechanisms underlying tumor spread and metastasis and how these mechanisms could be targeted.
Richard J. Wong
Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.
Sam S. Yoon
Physician-scientist Sam Yoon studies the role of tumor microenvironment in the progression and radiation response of sarcomas and gastric cancer.
James W. Young
Physician-scientist James Young studies innate and adaptive immunity against tumors and viruses stimulated by human dendritic cells.
Pat B. Zanzonico
Medical physicist Pat Zanzonico fosuses on radionuclide-based methods for detecting and localizing tumor hypoxia, immune effector-cell trafficking, patient-specific dosimetry for radionuclide therapies, and small-animal and molecular imaging.