Within Memorial Hospital, many scientists lead research laboratories, including some physician-scientists who apply insights from the clinic to their laboratory work. Our investigators conduct research ranging from analyzing genetic changes in patient tumor samples to developing new imaging techniques to studying the best ways to optimize radiation therapy delivery.
Learn more about our investigators who head basic and translational research laboratories within Memorial Hospital.
Howard I. Amols
Development of advanced radiation therapy treatment techniques including image-guided radiation therapy and intensity-modulated radiation therapy.
Cristina Antonescu
Molecular pathogenesis of soft tissue sarcomas and gastrointestinal stromal tumors.
Michael F. Berger
Massively parallel sequencing of tumor DNA for biomarker discovery and clinical diagnostics.
Michelle S. Bradbury
Development of translational, tumor-targeting, PET-optical silica nanoparticle probes for diagnostics, drug delivery, and sensing.
Jacqueline Bromberg
Aberrantly activated Stat3 and the mechanisms of Stat3-mediated transformation.
Brett S. Carver
Identification of molecular pathways involved in prostate cancer initiation and progression.
Timothy A. Chan
Identification and characterization of tumor suppressors in glioblastoma and breast cancer.
Yu Chen
The role of transcription factors that are critical for prostate cancer development.
Emily H. Cheng
The molecular mechanisms of cell death and their implications in tumorigenesis and cancer therapy.
Nai-Kong V. Cheung
Engineering of antibodies and immune cells to treat solid tumors in children.
Ping Chi
Genetic and epigenetic mechanisms of transcriptional regulation by oncogenic transcription factors in GIST and other solid tumors.
Amita Shukla Dave
Development of a program in multimodality imaging for head and neck cancer; development of new imaging criteria for prostate cancer.
Joseph O. Deasy
Integration and analysis of dose, imaging, and molecular data to predict outcomes and guide personalized treatments.
Ronald DeMatteo
Strategies to reduce immune subversion in gastrointestinal stromal tumor and liver cancer; immunobiology in liver cancer.
Liang Deng
Poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.
James Fagin
Pathogenesis of thyroid cancer and the role of oncogenic kinases.
Yuman Fong
Herpes-based oncolytic viral therapies in the treatment of malignancy.
Cyrus V. Hedvat
Identification of clinically relevant genomic alterations in acute myeloid leukemia.
James J. Hsieh
Development of novel therapeutics targeting cancer cell proliferation and establishment of a translational kidney cancer program.
Katharine C. Hsu
The biology of human natural killer cells and how they contribute to disease processes.
John L. Humm
Noninvasive imaging of the tumor microenvironment using nuclear imaging methods.
Jason T. Huse
Molecular pathogenesis of brain tumors, particularly high-grade gliomas.
Andrew Jackson
Relationship between radiotherapy dose-distributions and treatment outcome and the optimization of radiotherapy treatment planning.
Tari A. King
Molecular genetics of high-risk breast lesions and the transition from in situ to invasive breast carcinoma.
Moritz F. Kircher
Development of novel molecular imaging approaches with a focus on surface enhanced Raman spectroscopy and magnetic resonance imaging.
Jason A. Koutcher
Applications of magnetic resonance spectroscopy and imaging to enhance the therapeutic gain of different anti-neoplastic modalities.
Marc Ladanyi
Molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.
Douglas A. Levine
Genomic basis for prevention and control of ovarian and uterine carcinomas.
Ross L. Levine
Investigation of genetic basis of hematopoietic malignancies.
Jason S. Lewis
Development of radiopharmaceuticals for the imaging and therapy of cancer.
Gloria C. Li
Response of cells to stressors such as heat and radiation.
Philip O. Livingston
Tumor vaccinology, including approaches to augmenting the antibody and T cell response to defined cancer antigens.
Gikas S. Mageras
Radiation treatment planning and verification using CT images to guide radiation treatment and monitor and correct for patient internal and external movement during treatment delivery.
Babak J. Mehrara
Regulation of lymphatic regeneration after surgery and development of lymphedema.
Kenneth Offit
Cancer genetics: gene characterization, genetic/epidemiologic studies of cancer-predisposing alleles, and the therapeutic, prognostic, and psychosocial translation of these findings.
Ying-Xian Pan
Transcription regulation and function of opioid receptor genes.
Christopher Y. Park
Identification and characterization of molecular pathways that regulate normal and malignant stem cells in the hematopoietic system.
Vladimir Ponomarev
Development of new reporter genetic systems for specific applications such as sequential in-vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.
Milind Rajadhyaksha
Confocal microscopy for imaging of cancer; technology development and translational/clinical studies in skin and head-and-neck cancers.
Gary Schwartz
Identification of cell cycle inhibitors which promote chemotherapy induced apoptosis and their use in cancer therapy.
Sam Singer
Genomic alterations that define new targets for therapy in sarcoma.
Bhuvanesh Singh
Delineation of the role of ubiquitination in cancer pathogenesis.
David B. Solit
Human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
Viviane Tabar
In vivo applications of neural derivatives of pluripotent stem cells (iPS, ES); cancer stem cells in human brain tumors.
Laura H. Tang
Molecular pathogenesis of cell transformation in neuroendocrine neoplasms of the gastrointestinal tract and pancreas and adenocarcinoma of the stomach and gastrointestinal junction.
Sunitha B. Thakur
MR biomarkers for early detection and monitoring response to treatment.
Martin R. Weiser
Investigation of the mechanisms underlying tumor spread and metastasis and how these mechanisms could be targeted.
Richard J. Wong
Mechanisms of cancer cell chemotaxis in perineural invasion.
James W. Young
Innate and adaptive immunity against tumors and viruses stimulated by human dendritic cells.
Pat B. Zanzonico
Radionuclide-based methods for detecting and localizing tumor hypoxia, immune effector-cell trafficking, patient-specific dosimetry for radionuclide therapies, and small-animal and molecular imaging.
Investigators (from left) Marc Ladanyi, Samuel Singer, and Cristina Antonescu are collaborating to identify the genetic mutations that cause many types of soft tissue sarcoma.
