Research: New & Noteworthy

Neurons created from embryonic stem cells
Seeing the Light: How Engineered Nerve Cells Might Curb Parkinson’s Disease

A new tool called optogenetics is revealing clues about the function of a promising experimental therapy derived from stem cells.

Neurons created from embryonic stem cells
Pictured: José Baselga
Watch a Video of Our Physician-in-Chief for an Upcoming Ken Burns Film

MSK Physician-in-Chief José Baselga discusses the amazing progress that has been made in fighting cancer.

Pictured: José Baselga
Sandra D’Angelo and Jedd Wolchok
MSK Plays Critical Role in FDA Approval of New Melanoma Drug

A new treatment for advanced melanoma is the latest promising advance in immunotherapy tested in large part by our scientists.

Sandra D’Angelo and Jedd Wolchok
Stained pathology slides of a patient’s tumor (right) and of an organoid made from that tumor (left).
Five Fascinating Approaches to Cancer Science

From tropical plants and 3-D snapshots of worms to tiny particles that light up tumors, here’s a glimpse at some of the fascinating work MSK researchers pursued in 2014 as part of our quest to advance cancer science.

Stained pathology slides of a patient’s tumor (right) and of an organoid made from that tumor (left).
Pictured: Viviane Tabar
Investigators Use Stem Cells to Study Rare Pediatric Brain Tumors

Investigators have created the first-ever genetically engineered model of cancer made from human embryonic stem cells in culture.

Pictured: Viviane Tabar
(From left) MSK investigators Michael Berger, José Baselga, and Maurizio Scaltriti, and graduate student Pau Castel.
Study Reveals How Some Breast Cancers Become Resistant to Targeted Drugs

A study of one patient’s disease has clarified why tumors stop responding to a class of experimental drugs called PI3K inhibitors.

(From left) MSK investigators Michael Berger, José Baselga, and Maurizio Scaltriti, and graduate student Pau Castel.
Pictured: William Lee, Chris Sander & Nils Weinhold
Beyond the Usual Suspects: Study of Noncoding DNA Reveals New Mutations Linked to Cancer

In a study of patient tumor samples, researchers have found common mutations in parts of the genome that control gene regulation.

Pictured: William Lee, Chris Sander & Nils Weinhold
Pictured: Joao Xavier & Eric Pamer
Identification of Beneficial Bacteria May Lead to New Treatment for Common Infection

Clostridium difficile infections are a growing problem, but MSK researchers are looking for innovative ways to prevent and treat them.

Pictured: Joao Xavier & Eric Pamer
Cancer biologist Andrea Ventura
Disorderly DNA: Researchers Simulate a Common Cause of Lung Cancer

For the first time, Memorial Sloan Kettering scientists have created a mouse model that replicates a subtype of non-small cell lung cancer caused by a chromosomal rearrangement — a type of mutation that is common in cancers but thus far has been very difficult to study.

Cancer biologist Andrea Ventura
Pictured: Jorge Reis-Filho and Britta Weigelt
Genetic Mutations Found in Rare Salivary Tumor Could Improve Diagnosis and Treatment

Genetic alterations linked to a rare salivary cancer could also shed light on more common malignancies.

Pictured: Jorge Reis-Filho and Britta Weigelt