Research: New & Noteworthy

(From left) MSK investigators Michael Berger, José Baselga, and Maurizio Scaltriti, and graduate student Pau Castel.
Study Reveals How Some Breast Cancers Become Resistant to Targeted Drugs

A study of one patient’s disease has clarified why tumors stop responding to a class of experimental drugs called PI3K inhibitors.

(From left) MSK investigators Michael Berger, José Baselga, and Maurizio Scaltriti, and graduate student Pau Castel.
Pictured: William Lee, Chris Sander & Nils Weinhold
Beyond the Usual Suspects: Study of Noncoding DNA Reveals New Mutations Linked to Cancer

In a study of patient tumor samples, researchers have found common mutations in parts of the genome that control gene regulation.

Pictured: William Lee, Chris Sander & Nils Weinhold
Pictured: Joao Xavier & Eric Pamer
Identification of Beneficial Bacteria May Lead to New Treatment for Common Infection

Clostridium difficile infections are a growing problem, but MSK researchers are looking for innovative ways to prevent and treat them.

Pictured: Joao Xavier & Eric Pamer
Cancer biologist Andrea Ventura
Disorderly DNA: Researchers Simulate a Common Cause of Lung Cancer

For the first time, Memorial Sloan Kettering scientists have created a mouse model that replicates a subtype of non-small cell lung cancer caused by a chromosomal rearrangement — a type of mutation that is common in cancers but thus far has been very difficult to study.

Cancer biologist Andrea Ventura
Pictured: Jorge Reis-Filho and Britta Weigelt
Genetic Mutations Found in Rare Salivary Tumor Could Improve Diagnosis and Treatment

Genetic alterations linked to a rare salivary cancer could also shed light on more common malignancies.

Pictured: Jorge Reis-Filho and Britta Weigelt
Pictured: Pseudomonas aeruginosa
The Enemy’s Telltale Mark: Researchers Find Novel Way Body Defends against Harmful Bacteria

MSK researchers discover that the body senses and attacks harmful bacteria indirectly after the pathogens cause stress within the cells.

Pictured: Pseudomonas aeruginosa
DNA wrapped around histones
What Is Epigenetics?

Physician-scientist Omar Abdel-Wahab explains epigenetics, a growing field based on the study of genetic changes that are not part of the DNA code, and how it relates to cancer.

DNA wrapped around histones
Pictured: Scott Lowe
Researchers Uncover Potential Target for “Undruggable” Form of Liver Cancer

In taking a new approach to finding treatments for hepatocellular carcinoma, MSK scientists have uncovered a potential drug target for this highly aggressive cancer.

Pictured: Scott Lowe
Pictured: Experimental Brain Tumor
Genetic “Kill Switch” Could Make Cell Therapies Safer

Researchers have engineered a gene into therapeutic cells that allows them to turn off tumor growth if some of the cells become cancerous.

Pictured: Experimental Brain Tumor
Pictured: Nematode Worm Embryo
How to Build a Worm, in 3-D High Definition

Stunning movies captured in the lab of computational biologist Zhirong Bao reveal how cells divide, grow, and move around, as in a carefully choreographed dance, during the development of a nematode worm embryo.

Pictured: Nematode Worm Embryo