Research: New & Noteworthy

Report Highlights Advances Made at MSK That Are Changing Patients’ Lives

An annual report from an influential cancer group highlights three MSK studies that have advanced cancer research.

Neurons created from embryonic stem cells
Seeing the Light: How Engineered Nerve Cells Might Curb Parkinson’s Disease

A new tool called optogenetics is revealing clues about the function of a promising experimental therapy derived from stem cells.

Neurons created from embryonic stem cells
Pictured: José Baselga
Watch a Video of Our Physician-in-Chief for an Upcoming Ken Burns Film

MSK Physician-in-Chief José Baselga discusses the amazing progress that has been made in fighting cancer.

Pictured: José Baselga
Sandra D’Angelo and Jedd Wolchok
MSK Plays Critical Role in FDA Approval of New Melanoma Drug

A new treatment for advanced melanoma is the latest promising advance in immunotherapy tested in large part by our scientists.

Sandra D’Angelo and Jedd Wolchok
Stained pathology slides of a patient’s tumor (right) and of an organoid made from that tumor (left).
Five Fascinating Approaches to Cancer Science

From tropical plants and 3-D snapshots of worms to tiny particles that light up tumors, here’s a glimpse at some of the fascinating work MSK researchers pursued in 2014 as part of our quest to advance cancer science.

Stained pathology slides of a patient’s tumor (right) and of an organoid made from that tumor (left).
Pictured: Viviane Tabar
Investigators Use Stem Cells to Study Rare Pediatric Brain Tumors

Investigators have created the first-ever genetically engineered model of cancer made from human embryonic stem cells in culture.

Pictured: Viviane Tabar
(From left) MSK investigators Michael Berger, José Baselga, and Maurizio Scaltriti, and graduate student Pau Castel.
Study Reveals How Some Breast Cancers Become Resistant to Targeted Drugs

A study of one patient’s disease has clarified why tumors stop responding to a class of experimental drugs called PI3K inhibitors.

(From left) MSK investigators Michael Berger, José Baselga, and Maurizio Scaltriti, and graduate student Pau Castel.
Pictured: William Lee, Chris Sander & Nils Weinhold
Beyond the Usual Suspects: Study of Noncoding DNA Reveals New Mutations Linked to Cancer

In a study of patient tumor samples, researchers have found common mutations in parts of the genome that control gene regulation.

Pictured: William Lee, Chris Sander & Nils Weinhold
Pictured: Joao Xavier & Eric Pamer
Identification of Beneficial Bacteria May Lead to New Treatment for Common Infection

Clostridium difficile infections are a growing problem, but MSK researchers are looking for innovative ways to prevent and treat them.

Pictured: Joao Xavier & Eric Pamer
Cancer biologist Andrea Ventura
Disorderly DNA: Researchers Simulate a Common Cause of Lung Cancer

For the first time, Memorial Sloan Kettering scientists have created a mouse model that replicates a subtype of non-small cell lung cancer caused by a chromosomal rearrangement — a type of mutation that is common in cancers but thus far has been very difficult to study.

Cancer biologist Andrea Ventura