Faculty members of the Center for Stem Cell Biology (CSCB) work on a broad range of topics in stem cell research that includes developmental studies in model organisms, the directed differentiation of stem cells, mechanisms of self-renewal, pluripotency and reprogramming, the relationship of stem cells and cancer, small molecule approaches, and the use of stem cells as a model of human disease. In addition, a close collaboration between the CSCB and Center for Cell Engineering at Memorial Sloan-Kettering aims at realizing the potential of stem cells for the next generation of cell-based therapies.
Select from the list below to learn more about our members.
Executive Committee
Lorenz P. Studer, MD
Director, Center for Stem Cell Biology
Developmental Biology Program
Research interests: Stem cell self-renewal and differentiation, stem cells as a model of development and disease, stem cell transplantation in neural disease, ALS, Parkinson's disease, development of HTS assays in stem cell biology
Michel Sadelain, MD, PhD
Director, Center for Cell Engineering
Molecular Pharmacology and Chemistry Program
Research interests: Genetic engineering, lentiviral-mediated gene transfer, transgene regulation, beta-thalessemia, investigating control of transgene expression in vivo in hematopoietic stem cells and how to augment immune responses against tumor cells
Robert Benezra, PhD
Cancer Biology and Genetics Program
Research interests: Study of the role of Id proteins in the maintenance of embryonic and adult stem cells
Alan Hall, PhD
Chair, Cell Biology Program
Research interests: Rho and Ras family GTPases in the regulation of animal cell biology, signal transduction pathways in neuronal and epithelial morphogenesis and in the biology of glioma stem-like cells
Kathryn V. Anderson, PhD
Chair, Developmental Biology Program
Research interests: The role of cilia in SHH signaling, genetic control of mouse embryonic development
Faculty
Raju S. K. Chaganti, PhD
Department of Medicine
Cell Biology Program
Research interests: Study of germ cell tumors, mechanisms of differentiation in pluripotent stem cell lines
Bayard D. Clarkson, MD
Department of Medicine
Molecular Pharmacology and Chemistry Program
Research interests: Genetic abnormalities responsible for clinical manifestations of CML, Ph+ALL, chronic neutrophilic leukemia
Robert J. Downey, MD
Department of Surgery
Research interests: Role of stem cells in the development of cancer, the potential role of stem cells derived from bone marrow in the development of epithelial cancers
Anna-Katerina Hadjantonakis, PhD
Developmental Biology Program
Research interests: Morphogenesis of the early mammalian embryo, embryonic stem and progenitor cells, tools and methods for in vivo imaging
Danwei Huangfu, PhD
Developmental Biology Program
Research interests: Directed differentiation of pluripotent stem cells, induced pluripotent stem cells, genetic lineage programming and reprogramming, pancreatic development and precursor cell biology
Maria Jasin, PhD
Developmental Biology Program
Research Interests: Mechanisms of DNA repair and homologous recombination, genetic engineering of somatic and stem cell populations, germ-line recombination in mouse
Alexandra L. Joyner, PhD
Developmental Biology Program
Research interests: Mechanisms of cerebellar development, SHH signaling, adult neural stem cell biology
Michael Kharas, PhD
Molecular Pharmacology and Chemistry Program
Role of RNA regulatory molecules such as Musashi-2 in normal and leukemic hematopoietic stem cells (HSCs), identification of factors that control HSC self-renewal and differentiation
Kitai Kim, PhD
Cancer Biology and Genetics Program
Role of DNA methylation and impact of epigenetic memory on biology of induced pluripotent stem cells, novel strategies to develop histocompatible pluripotent stem cell lines
Elizabeth H. Lacy, PhD
Developmental Biology Program
Research interests: Stem cell differentiation, gastrulation, organogenesis
Eric Lai, PhD
Developmental Biology Program
Research Interests: MicroRNA biology, the role of notch and miRNAs in developmental patterning and in neural stem cell populations
Joan Massagué, PhD
Chair, Cancer Biology and Genetics Program
Howard Hughes Medical Institute Investigator
Research interests: Role of TGF-beta signaling, cancer stem cells, metastatic behavior
Christine Mayr, MD, PhD
Cancer Biology and Genetics Program
Research interests: Functional role and regulation of alternative polyadenylation during ES cell differentiation into different cell types
Malcolm Moore, DPhil
Cell Biology Program
Department of Medicine
Research interest: Human and mouse hematopoietic stem cell biology under normal, neoplastic, and genetic diseases conditions; differentiation of mouse and human embryonic stem cells towards hematopoietic and endothelial fates
Mark Ptashne, PhD
Molecular Biology Program
Research interests: Basic mechanisms of gene regulation, primarily in yeast, but with an eye to understanding many basic aspects of biological regulation including cell fate specification and cell reprogramming towards pluripotency
Mark J. Tomishima, PhD
Director, Sloan-Kettering Institute Stem Cell Facility
Developmental Biology Program
Research interests: Directed differentiation of pluripotent stem cells, induced pluripotent stem cells, genetic modification of stem cells, stem cell technology
Richard J. O'Reilly, MD
Chair, Department of Pediatrics
Chief, Pediatric Bone Marrow Transplant Service
Research interests: Bone marrow transplantation, hematopoietic stem cells and transplantation therapy with particular focus on pediatric patients
Songhai Shi, PhD
Developmental Biology Program
Research interests: Mechanisms underlying the mammalian CNS development, mechanism of assymetric cell division in neural development
Urs Rutishauser, PhD
Cell Biology Program
Research interests: PSA-NCAM biology, brain repair and plasticity, integration of stem cells into host tissue, spinal cord repair
Chris Sander, PhD
Chair, Computational Biology Program
Research interests: Computational biology, stimulation of biological processes including stem cell behavior and pluripotency
Viviane S. Tabar, MD
Department of Neurosurgery
Research interests: Neural and embryonic stem cells in brain repair following injury or disease, disease areas, Parkinson's disease and ALS (Amyotrophic Lateral Sclerosis), radiation injury to the brain, cancer stem cells, glioma biology and tumor angiogenesis
Marcel R. M. van den Brink, MD, PhD
Chief, Adult Bone Marrow Transplantation Service
Immunology Program
Research interests: Hematopoietic stem cells transplantation, transplantation immunology including graft versus host disease, engineering of lymphoid precursors for adaptive immunotherapies
Hans-Guido Wendel, MD
Cancer Biology and Genetics Program
Research interests: Stem cell based tumor models, iPSC-derived tissue and the risk of cancer, generation of safe iPSC cells
Richard Mark White, MD, PhD
Cancer Biology and Genetics Program
Research interests: Modeling specification of neural crest lineages and melanoma biology in the zebrafish
