The Center for Stem Cell Biology (CSCB) was awarded a grant from the New York State Department of Health and the Empire State Stem Cell Board to support training in stem cell research. The grant sponsors five postdoctoral fellows who show exceptional potential for making significant contributions to the field of stem-cell-related research. Our trainees have the opportunity to take advantage of the unique resources available at Memorial Sloan-Kettering, ranging from basic developmental biology and genetic lineage tracing to pluripotency, directed differentiation, stem cell engineering, chemical/genetic screening, and regenerative medicine, including clinical-grade cell processing.
Celia Andreu-Agullo, PhD, Research Fellow, Developmental Biology Program
Project Title: Role of Arsenic-Resistant Protein 2 (Ars2) in the Regulation of Adult Neural Stem Cells
Fiona Bangs, PhD, Research Fellow, Developmental Biology Program
Project Title: The Role of Cilia and Centrosomes in Self-Renewal and Differentiation of Mouse Embryonic Stem Cells
Federico González Grassi, PhD, Research Fellow, Developmental Biology Program
Project Title: Understanding the Mechanisms That Govern the Reprogramming of a Somatic Cell to a Pluripotent State.
Jorge Mansilla-Soto, PhD, Research Fellow, Molecular Pharmacology and Chemistry Program
Project Title: Gene Repair and Erythroid Differentiation Potential of Sickle-Cell-Anemia-Induced Pluripotent Stem Cells
Elsa Vera, PhD, Research Fellow, Developmental Biology Program
Project Title: Accelerating in Vitro Neural Aging by Manipulations of Telomerase Function and Its Application for Modeling Late-Onset Disease
Publications and Presentations
Andreu-Agullo C, Maurin T, Thompson CB, Lai EC. Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature. 2011 Dec 25;481(7380):195-8. doi: 10.1038/nature10712.
Federico González, Daniela Georgieva, Fabio Vanoli, Zhong-Dong Shi, Matthias Stadtfeld, Thomas Ludwig, Maria Jasin, Danwei Huangfu. Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State. Cell Rep. 2013 Mar 28;3(3):651-60. doi: 10.1016/j.celrep.2013.02.005. Epub 2013 Mar 7.
Dai Q, Andreu-Agullo C, Insolera R, Wong LC, Shi SH, Lai EC. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development. 2013 May;140(9):1892-902. doi: 10.1242/dev.087502.