Center for Stem Cell Biology: Training Grants for Postdoctoral Fellows

The Center for Stem Cell Biology (CSCB) was awarded a grant from the New York State Department of Health and the Empire State Stem Cell Board to support training in stem cell research. The grant sponsors five postdoctoral fellows who show exceptional potential for making significant contributions to the field of stem-cell-related research. Our trainees have the opportunity to take advantage of the unique resources available at Memorial Sloan Kettering, ranging from basic developmental biology and genetic lineage tracing to pluripotency, directed differentiation, stem cell engineering, chemical/genetic screening, and regenerative medicine, including clinical-grade cell processing.

Current Trainees

Kosuke Funato, PhD, Research Fellow, Department of Neurosurgery

Project Title: Human ES-based modeling of pediatric glioblastoma by histone mutations

Pictured: Qiong WangQiong Wang, PhD, Research Scholar, Cancer Biology & Genetics Program

Project Title: p53 acts as a switch factor to license master differentiation genes expression by TGF-beta signals

Pictured: Xinjun ZhangXinjun Zhang, PhD, Research Scholar, Developmental Biology Program

Project Title: Accelerated Generation of Functional Cortical Neurons from Human Embryonic Stem Cells Using Combinatorial Small-Molecule Treatment

Pictured: Zengrong ZhuZengrong Zhu, PhD, Research Fellow, Developmental Biology Program

Project Title: Study Pancreatic Development and Diabetes using hESC-based System

Bastian Zimmer, PhD, Research Fellow, Developmental Biology Program

Project Title: Tailored hPSC-based cell therapy for hypopituitarism

Publications and Presentations

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.He M, Subramanian R, Bangs F, Omelchenko T, Liem Jr KF, Kapoor TM, Anderson KV. Nat Cell Biol. 2014 Jun 22. doi: 10.1038/ncb2988. [Epub ahead of print]

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells.González F, Zhu Z, Shi ZD, Lelli K, Verma N, Li QV, Huangfu D. Cell Stem Cell. 2014 Jun 11. pii: S1934-5909(14)00205-7. doi: 10.1016/j.stem.2014.05.018. [Epub ahead of print]

Andreu-Agullo C, Maurin T, Thompson CB, Lai EC. Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature. 2011 Dec 25;481(7380):195-8. doi: 10.1038/nature10712.

Federico González, Daniela Georgieva, Fabio Vanoli, Zhong-Dong Shi, Matthias Stadtfeld, Thomas Ludwig, Maria Jasin, Danwei Huangfu. Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State. Cell Rep. 2013 Mar 28;3(3):651-60. doi: 10.1016/j.celrep.2013.02.005. Epub 2013 Mar 7.

Dai Q, Andreu-Agullo C, Insolera R, Wong LC, Shi SH, Lai EC. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development. 2013 May;140(9):1892-902. doi: 10.1242/dev.087502.

Former Trainees

Pictured: Celia Andreu-AgulloCelia Andreu-Agullo, PhD, Research Fellow, Developmental Biology Program

Project Title: Role of Arsenic-Resistant Protein 2 (Ars2) in the Regulation of Adult Neural Stem Cells

Pictured: Fiona BangsFiona Bangs, PhD, Research Fellow, Developmental Biology Program

Project Title: The Role of Cilia and Centrosomes in Self-Renewal and Differentiation of Mouse Embryonic Stem Cells

Pictured: Federico González GrassiFederico González Grassi, PhD, Research Fellow, Developmental Biology Program

Project Title: Understanding the Mechanisms That Govern the Reprogramming of a Somatic Cell to a Pluripotent State.

Pictured: Jorge Mansilla-SotoJorge Mansilla-Soto, PhD, Research Fellow, Molecular Pharmacology and Chemistry Program

Project Title: Gene Repair and Erythroid Differentiation Potential of Sickle-Cell-Anemia-Induced Pluripotent Stem Cells

Pictured: Elsa VeraElsa Vera, PhD, Research Fellow, Developmental Biology Program

Project Title: Accelerating in Vitro Neural Aging by Manipulations of Telomerase Function and Its Application for Modeling Late-Onset Disease