SK-CO-1 is a human colorectal adenocarcinoma cell line that displays epithelial morphology and grows in adherent tissue culture. In culture, these cells are capable of invading through an extracellular matrix, such as Matrigel. SK-CO-1 cells do not form tumors when injected into immunocompromised mice, and rarely form colonies in soft agar. These cells have oncogenic mutations in K-Ras (G12V) and adenomatous polyposis coli (APC) proteins.
This cell line was established in 1972 from a metastatic site (ascites) in a 65-year-old Caucasian male with colorectal adenocarcinoma.
- Lloyd J. Old, MD, former William E. Snee Chair in Cancer Immunology, Memorial Sloan Kettering Cancer Center; former Director, New York Branch, Ludwig Institute for Cancer Research
- Germain Trempe, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Fogh J et al. (1977) Absence of HeLa cell contamination in 169 cell lines derived from human tumors. Journal of the National Cancer Institute 58: 209-214 (PubMed ID: 833871)
- Trainer DL et al. (1988) Biological characterization and oncogene expression in human colorectal carcinoma cell lines. International Journal of Cancer 41: 287-296 (PubMed ID: 3338874)
This cell line may be licensed nonexclusively for research or commercial purposes.
Tingting Zhang-Kharas, PhD