Tangible Material: SK-MEL-1: Human Melanoma Cell Line

SK2004-052

Description

SK-MEL-1 is the first of a series of melanoma cell lines established from patient-derived tumor samples. This cell line is grown in suspension culture and expresses mutant B-Raf (V600E) and wildtype N-Ras.

Source

This cell line was established in 1966 from a metastatic site (thoracic lymph duct) in a 29-year-old Caucasian male with malignant melanoma.

Inventors

Herbert F. Oettgen, MD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center

Key References

  • Oettgen HF et al. (1968) Suspension culture of a pigment-producing cell line derived from a human malignant melanoma. Journal of the National Cancer Institute 41: 827-843 (Pubmed ID: 4879578)
  • Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
  • Xing F et al. (2012) Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E) BRAF. Oncogene 31(4):446-457 (PubMed ID: 21725359)

Licensing Information

This cell line may be licensed nonexclusively for research or commercial purposes.

Contact Information

Tingting Zhang-Kharas, PhD
Licensing Manager
Tel: 646-888-1083
Stage of Development
Ready to use
Technology Types
Indications