SK-MM-2 is a multiple myeloma cell line that grows in suspension culture. These cells display plasmacytoid morphology and have a doubling time of approximately 60 hours. SK-MM-2 cells do not express the Epstein-Barr virus nuclear antigen. These cells express the pan-B-cell marker B1 and the late B-cell/plasma cell markers BL3, OKT10, and PCA-1, but do not express any T-lymphocyte, myeloid, or early B-lymphocyte markers. These cells secrete kappa light chains, but do not secrete any heavy chains. In addition, SK-MM-2 cells also express elevated levels of Cyclin D1 mRNA.
This cell line was established in 1982, from a leukapheresis sample of peripheral blood, from a 54-year-old male, of unknown ethnicity, with plasma cell leukemia.
Alan N. Houghton, MD, Attending Physician, Department of Medicine, Memorial Hospital; and Member, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Eton O et al. (1989) Establishment and characterization of two human myeloma cell lines secreting kappa light chains. Leukemia 3: 729-735 (PubMed ID: 2506399)
- Sáez B et al. (2007) Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes. Cancer Genetics and Cytogenetics 175: 65-68 (PubMed ID: 17498561)
This cell line may be licensed nonexclusively for research or commercial purposes.
Tingting Zhang-Kharas, PhD