SK-OV-3 is a human ovarian cancer cell line with epithelial-like morphology. These cells are resistant to tumor necrosis factor and to other cytotoxic drugs such as diphtheria toxin, cisplatin, and adriamycin. The SK-OV-3 cell line forms colonies in soft agar, which serves as a surrogate assay for tumorigenicity. Intra-peritoneal injection of these cells into immunocompromised mice results in the growth of tumors resembling clear cell adenocarcinoma, within two to three months.
This cell line was established in 1973 from the ascites of a 64-year-old Caucasian female with adenocarcinoma of the ovary.
- Lloyd J. Old, MD, former William E. Snee Chair in Cancer Immunology, Memorial Sloan Kettering Cancer Center; former Director, New York Branch, Ludwig Institute for Cancer Research
- Germain Trempe, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
- Shaw TJ et al. (2004) Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer. Molecular Therapy 10: 1032–1042 (PubMed ID: 15564135)
This cell line may be licensed nonexclusively for research or commercial purposes.
Tingting Zhang-Kharas, PhD