Malme-3M is a malignant human melanoma cell line that displays fibroblast-like morphology and grows in mixed culture (adherent-suspension). This cell line has been shown to be dependent upon micropthalmia-associated transcription factor (MITF) activity for growth and survival. Malme-3M cells form tumors when injected into immunocompromised mice. These cells express mutant B-Raf (V600E) and wildtype N-Ras.
This cell line was established in 1975 from a metastatic site (lung) in a 43-year-old Caucasian male with metastatic melanoma.
- Jorgen Fogh, PhD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Germaine Trempe, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
· Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute
59: 221-226 (PubMed ID: 327080
· Xing F et al. (2012) Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF. Oncogene
31: 446-457 (PubMed ID: 21725359
· Ma J et al. (2013) HER2 as a Promising Target for Cytotoxicity T Cells in Human Melanoma Therapy. PLoS One
8: e73261 (PubMed ID: 24015299
Malme-3, a normal skin fibroblast cell line, isolated from the same patient as the Malme-3M melanoma cell line, is also available for licensing.
This cell line may be licensed nonexclusively for research or commercial purposes.
Tingting Zhang-Kharas, PhD