Tangible Material: SK-JHRCC-120: Human Renal Cancer Cell Line

SK-JHRCC-120

 

Description

SK-JHRCC-120 is a human clear cell renal cell carcinoma (ccRCC) cell line that displays epithelial morphology and grows in adherent culture. This cell line forms big colonies when plated in soft agar. The SK-JHRCC-120 cells are a useful preclinical model to study renal cancer. They form tumors when inoculated subcutaneously in immunocompromised NSG mice. These xenografts are insensitive to Sunitinib (oral, small molecule, multi-targeted receptor tyrosine kinase inhibitor, approved for the treatment of renal cell carcinoma) in vivo.

Source

This cell line was established in 2013 from the primary tumor of a 49-year-old Caucasian male with clear cell carcinoma of the kidney and was refractory to treatment with Sunitinib.

Inventors

  • James J. Hsieh, MD, PhD, Laboratory Head, Memorial Hospital Research Laboratories, Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center
  • Emily H. Cheng, MD, PhD, Laboratory Head, Memorial Hospital Research Laboratories, Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center
  • Yiyu Dong, PhD, Research Associate, Hsieh Laboratory, Memorial Hospital Research Laboratories, Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center

Licensing Information

This cell line may be licensed nonexclusively for research or commercial purposes.

Contact Information

Tingting Zhang-Kharas, PhD
Licensing Assistant
Tel: 646-888-1083; Fax: 646-888-1120
Stage of Development
Ready to use
Technology Types