SK-N-MC-IXC is a twice-sub-cloned cell line derived from the SK-N-MC cell line. These cells share many characteristics with the parental cell line. Unlike the SK-N-MC cell line, however, these cells contain a variable number of double-minute chromosomes. At the time of establishment, double-minute chromosomes were present in almost 90 percent of the cells examined and varied in number and size. Like the parental cell line, the SK-N-MC-IXC cells have little or no dopamine-b-hydroxylase activity. They do, however, have significantly increased choline acetyltransferase activity compared to the parental SK-N-MC cell line.
This cell line was derived from the SK-N-MC-IX subclone of the parental SK-N-MC cell line. The parental cell line was established in 1971 from a metastatic site (supra-orbital region) in a 14-year-old Caucasian female with an Askin’s tumor.
- June L. Biedler, PhD, former Chairman, Cell Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Barbara A. Spengler, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Biedler JL et al. (1973) Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Research 33: 2643-2652 (PubMed ID: 4748425)
- Biedler JL et al. (1978) Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Research 38: 3751-3757 (PubMed ID: 29704)
This cell line may be licensed nonexclusively for research or commercial purposes.
Tingting Zhang-Kharas, PhD