SK-NEP-1 was originally described as an anaplastic Wilms-tumor/renal-cancer cell line. It has, however, been reclassified as a cell line belonging to the Ewing sarcoma family of tumors, since these cells harbor the oncogenic EWS-FLI1 chromosomal rearrangement. These cells express mutant p53 and are known to form tumors in immunocompromised mice.
This cell line was established in 1971 from a metastatic site (pleural effusion) in a 25-year-old Caucasian female.
- Germain Trempe, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Jorgen Fogh, PhD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
- Smith MA et al. (2008) SK-NEP-1 and Rh1 are Ewing family tumor lines. Pediatric Blood & Cancer 50: 703-706 (PubMed ID: 17154184)
This cell line may be licensed nonexclusively for research or commercial purposes.
Tingting Zhang-Kharas, PhD