SK-UT-1 is a human uterine leiomyosarcoma cell line that grows in adherent culture. This cell line has little or no phosphorylated retinoblastoma protein compared to the SK-UT-1B cells. SK-UT-1 cells are capable of forming tumors when inoculated in immunocompromised mice.
This cell line was established in 1972 from a 75-year-old Caucasian female with a uterine mixed mesodermal tumor consistent with leiomyosarcoma grade III.
- Lloyd J. Old, MD, former William E. Snee Chair in Cancer Immunology, Memorial Sloan Kettering Cancer Center; former Director, New York Branch, Ludwig Institute for Cancer Research
- Germaine Trempe, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (Pubmed ID: 327080)
- Ganiatsas S et al. (2001) A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT. Oncogene 20: 3641-50 (PubMed ID: 11439327)
- Li B et al. (2013) Curcumin induces cross-regulation between autophagy and apoptosis in uterine leiomyosarcoma cells. International Journal of Gynecological Cancer 23: 803-808 (PubMed ID: 23532091)
This cell line may be licensed nonexclusively for research or commercial purposes.
Tingting Zhang-Kharas, PhD