Tangible Material: HT-29: Human Colorectal Adenocarcinoma Cell Line

SK 809

Description

HT-29 is a human colorectal adenocarcinoma cell line with epithelial morphology. These cells are sensitive to the chemotherapeutic drugs 5-fluorouracil and oxaliplatin, which are standard treatment options for colorectal cancer. In addition to being a xenograft tumor model for colorectal cancer, the HT-29 cell line is also used as an in-vitro model to study absorption, transport, and secretion by intestinal cells. Under standard culture conditions, these cells grow as a nonpolarized, undifferentiated multilayer. Altering culture conditions or treating the cells with various inducers, however, results in a differentiated and polarized morphology, characterized by the redistribution of membrane antigens and development of an apical brush-border membrane.

Source

This cell line was established in 1964 from the primary tumor of a 44-year-old Caucasian female with colorectal adenocarcinoma.

Inventors

Jorgen Fogh, PhD, formerly at Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center

Key References

  • Fogh J et al. (1977) One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59: 221-226 (PubMed ID: 327080)
  • Cohen E at al. (1999) Induced differentiation in HT29, a human colon adenocarcinoma cell line. Journal of Cell Science 112: 2657-2666 (PubMed ID: 10413674)
  • Nautiyal J et al. (2011) Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells. Journal of Molecular Signaling 6: 7 (PubMed ID: 21774804)

Licensing Information

This cell line may be licensed nonexclusively for research or commercial purposes. 

Contact Information

Tingting Zhang-Kharas, PhD
Licensing Assistant
Tel: 646-888-1083; Fax: 646-888-1120
 
Stage of Development
Ready to use
Technology Types
Indications