Some non-small cell lung cancers (NSCLC) are caused by a change, or mutation, in a gene called EGFR. Afatinib is an FDA-approved pill that has been shown to be active against cancers with this mutation. Erlotinib is another pill used to treat NSCLC with mutated EGFR. Prior studies have suggested that giving erlotinib for two years after surgery may delay cancer recurrence, but it is unknown if two full years of treatment are necessary.
In this study, researchers are comparing the safety and effectiveness of giving afatinib for three months versus two years in patients with EGFR-mutant NSCLC who have had their tumors surgically removed and have finished taking all standard therapies recommended by their doctors. Patients will be randomly assigned to receive afatinib, one pill by mouth daily, for three months or for two years.