FGFR 1, FGFR 2, and FGFR 3 are molecules that form “receptors” on the surface of cells. These receptors are molecular switches that, when activated, can fuel cellular growth in various ways. Cancer cells can depend on FGFR 1, FGFR 2, and FGFR 3 whenever one of these receptors is in an overactive state and provides a growth advantage over healthy cells.
Such overactivation in FGFR 1, FGFR 2, and FGFR 3 is found in various types of cancer. It is brought about by changes (mutations) in the genetic blueprint of the cell that result in the receptors constantly being switched in the “on” position. Other cancer cells simply produce larger amounts of the receptor molecules through mechanisms called “amplifications” or “translocations.” One can summarize these different molecular changes as “alterations” in FGFR 1, FGFR 2, and FGFR 3.
Debio1347 is an investigational drug designed to inhibit cancer growth by potently blocking the activity of FGFR 1, FGFR 2, and FGFR 3. It should therefore slow down the growth of and kill cancer cells that depend on the activity of these molecules. Debio1347 is a pill that is taken orally (by mouth) each day.
In this study, researchers want to find the highest dose of Debio1347 that can be given safely in patients with advanced cancers that contain alterations in FGFR 1, FGFR 2, and/or FGFR 3. In doing so, they also plan to gain an early understanding of how well this drug can control cancers with overactive FGFR 1, FGFR 2, or FGFR 3.