Video: A Personalized Approach to Cancer Screening and Prevention in People with Lynch Syndrome

Cancer genetics expert Zsofia Stadler of Memorial Sloan-Kettering says the risk of developing gastrointestinal, gynecologic, or other types of cancer associated with Lynch syndrome depends on the specific genetic mutation a person has. MLH1 and MSH2 are the most common genetic mutations associated with Lynch syndrome, but scientists have identified additional mutations such as MSH6, PMS2, and TAC/STD1. New information about the risk of cancer associated with different genetic mutations could pave the way for a more personalized approach to cancer screening and prevention. A diagnostic test of stool or tumor cells that looks for methylated DNA, which occurs in cancer cells, may offer a less invasive alternative to colonoscopy.