Molecular Biology Program
The Kenneth Marians Lab
Research
![Ken Marians](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/1514/person/marians_141104_10_3x2.jpg?h=10d202d3)
Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and (ii) the mechanisms by which chromosomes are condensed and separated during cell division. Our studies on the consequences of replication fork blockage and restart utilize purified replication, recombination, and transcription proteins in various well-defined systems reconstituted in vitro that model all steps of these events. Our studies on chromosome condensation and segregation utilize a combination of biochemical, cell biological, and molecular genetic approaches.
Research Projects
![The Ken Marians Lab](https://www.mskcc.org/sites/default/files/node/1514/3x2/marians_lab_180511_05_1200x800.jpg)
Featured News
![Memorial Sloan Kettering molecular biologist Jerard Hurwitz](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/170956/3x2/hurwitz-jerard_1200x800.jpg)
![Kenneth Marians and Louis V. Gerstner, Jr.](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/165865/3x2/cbb2c9fe-5588-4e39-8e3c-88b6083d6434.jpeg)
![Molecular biologist Ken Marians and cell biologist Michael Overholtzer](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/165589/3x2/gsk_3_1200x800.jpg)
Publications Highlights
People
![Ken Marians](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/1514/person/marians_141104_10_3x2.jpg?h=10d202d3)
Kenneth J. Marians, PhD
William E. Snee Chair
- Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.
- PhD, Cornell University
- [email protected]
- Email Address
- 212-639-5890
- Office Phone
Members
![Rupesh Kumar](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/155959/3x2/kumar_rupesh_180511_09_1200x800.jpg?h=10d202d3)
![Soon Bahng](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2383/3x2/bahng_180511_10_1200x800.jpg?h=10d202d3)
![Rupesh Kumar](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/155959/3x2/kumar_rupesh_180511_09_1200x800.jpg?h=10d202d3)
Senior Research Scientist
Senior Research Scientist
![Soon Bahng](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2383/3x2/bahng_180511_10_1200x800.jpg?h=10d202d3)
Senior Research Assistant
![Chong Lee](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2382/3x2/lee_chong_180511_10_1200x800.jpg?h=10d202d3)
Research Assistant
![Jan-Gert Brüning](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/155947/3x2/bruening_180511_12_1200x800.jpg?h=10d202d3)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2381/image/426370.jpg?h=6fa44599)
![Avradip Chatterjee](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/155953/3x2/chatterjee_180511_07_1200x800.jpg?h=10d202d3)
![Philip Nevin](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/155956/3x2/nevin_180511_17_1200x800.jpg?h=10d202d3)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4415/image/422841.jpg?h=881888aa)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4413/image/422801.jpg?h=881888aa)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2384/image/191557.jpg?h=6fa44599)
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4416/image/422848.jpg?h=6fa44599)
Lab Alumni
![Jan-Gert Brüning](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/155947/3x2/bruening_180511_12_1200x800.jpg?h=10d202d3)
Senior Research Scientist
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2381/image/426370.jpg?h=6fa44599)
Senior Research Technician
![Avradip Chatterjee](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/155953/3x2/chatterjee_180511_07_1200x800.jpg?h=10d202d3)
Postdoctoral Fellow
![Philip Nevin](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/155956/3x2/nevin_180511_17_1200x800.jpg?h=10d202d3)
Postdoctoral Fellow
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4415/image/422841.jpg?h=881888aa)
Research Fellow
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4413/image/422801.jpg?h=881888aa)
Graduate Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4417/image/422855.jpg?h=2c80a62f)
Graduate Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/2384/image/191557.jpg?h=6fa44599)
Graduate Student
![](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/4416/image/422848.jpg?h=6fa44599)
Research Fellow
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Career Opportunities
Get in Touch
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Kenneth J. Marians discloses the following relationships and financial interests:
No disclosures meeting criteria for time period
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].