Philip Kantoff is Chair of Memorial Sloan Kettering’s Department of Medicine. He came to MSK in November 2015 from the Dana-Farber Cancer Institute and Harvard Medical School.
As Chair of the Department of Medicine, what do you do?
I oversee the medical treatment of people with cancer — treatments like chemotherapy, targeted therapies, and immunotherapies. My department also leads the development of new approaches to drug treatments. Heading a department of medicine at a cancer center is very different from doing that job at a regular hospital. Although we have specialists in fields beyond oncology, the focus of everyone here is cancer.Back to top
What is your focus at MSK?
A main emphasis for me is mentorship. One of the first things I did when I started was move the office for the medical oncology fellows next to mine. These fellows, who are getting specialized training in cancer care, are the future of oncology. Now it’s easier for all the fellows to come seek my guidance, whether it’s about patient care or career advice. I take pride in helping others succeed.
Another focus has been fostering better partnerships among different members of the healthcare team, medical staff, and administration, as well as building bridges between laboratory scientists and clinical investigators.
What cancers do you specialize in?
My focus is genitourinary cancers, especially prostate cancer and testicular cancer. Although the treatment for men with early-stage prostate cancer is usually surgery or radiation rather than drugs, which is my main area of expertise, about half of the patients I see have early-stage disease. They’re trying to decide what course to take with their treatment. I triage them, advise them, and become their quarterback. I’ve always enjoyed developing close relationships with my patients.Back to top
You’re a big proponent of active surveillance in prostate cancer, monitoring a person’s disease instead of directly treating it. Why?
For select men whose disease has not spread outside the prostate and is not aggressive, active surveillance may be the best option. When I tell my patients, “You don’t have to do anything. We’ll just keep an eye on you,” they’re usually very happy. They embrace active surveillance because they know the side effects of treatment can be significant.Back to top
What goes on in your lab?
Prostate cancer behaves very differently in different people. We’re trying to understand the genetic variations that make some cancers more aggressive than others as well as how these cancers develop resistance to therapies. We hope to develop better ways to predict which cancers are most likely to become aggressive, so we can prevent them from returning after initial treatment.Back to top
What research are you most excited about right now?
A few years ago, I was part of a multicenter collaboration that found about one-quarter of men with advanced prostate cancer have inherited gene mutations related to DNA repair, such as BRCA1 and BRCA2. Now that we know this, we can use drugs developed to treat BRCA-associated ovarian and breast cancers on prostate cancer as well.Back to top
How did you get interested in the field?
After my medical training, I did a postdoctoral research fellowship at the National Institutes of Health. At that time, the mid-1980s, it seemed that cancer was the area of medicine that was most amenable to molecular biology.Back to top
You’re a native New Yorker, but you’ve spent most of your career in Boston. How is it being back?
All three of my kids live here. It’s nice being close to them. Also, I’m a huge fan of New York sports teams, especially the Yankees and the Giants. It’s a lot easier to be a Yankees fan here than it is in Boston.Back to top