On Cancer: Chemical Biology

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16 Blog posts found

In The Lab

Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.

Two clusters of colored blobs with a diagram in the middle

Science Byte

Scientists Discover Keys to Immune Response against Anthrax

Researchers clarify how the immune system activates an inflammatory defense against pathogens.

Ribbon diagram of an anthrax protein.

Feature

Remembering Jerard Hurwitz, a Giant of Molecular Biology

MSK colleagues pay tribute to molecular biologist Jerard Hurwitz’s scientific accomplishments and passion for discovery.

Memorial Sloan Kettering molecular biologist Jerard Hurwitz

In the Clinic

Experimental Cancer Drug Developed at MSK Leads to New Approach for Treating Alzheimer's Disease

A family of drugs developed at MSK targets disrupted processes in cells in diseases related to aging.

Chemical biologist Gabriela Chiosis in a laboratory

Q & A

Building a Safer Opioid: MSK Research Seeks to Develop New Ways to Relieve Pain

Science could lead to a new type of opioid drug that blocks pain but has a lower potential for addiction or abuse.

MP1104 binding to the kappa opioid receptor

In the Lab

Mirror-Image Chemistry Enables New Approach for Targeting an “Undruggable” Cancer-Causing Protein

MSK chemists are focusing on developing small-molecule drugs to target KRas, an important cancer protein.

Left-handed and right-handed KRas molecules

In the Lab

Researchers Gain Insight into How a Drug Fires Up an Immune Response to Cancer

Scientists have learned that a drug activates a form of highly inflammatory programmed cell death called pyroptosis — a discovery that sheds light on immune function.

Image of fireball-type explosion on black background.

In the Lab

Communal Behavior within Cells Makes Cancers Easier to Target

Findings about proteins called molecular chaperones are shedding new light on possible approaches to cancer treatment.

Bees in a hive

In the Lab

New Drug Developed at MSK Starves Acute Myeloid Leukemia of a Signaling Fix

An innovative collaboration between basic scientists and clinical researchers has led to a promising new drug for AML.

Light micrograph of white blood cells from a patient with acute myeloid leukemia.

In the Lab

Uncharted Waters: The Making of a New Cancer Drug

A team of scientists is combining sophisticated chemistry and experiments in zebrafish to develop a new cancer drug that shows early potential against melanoma and metastatic breast cancer.

Portrait of a live zebrafish with dark patterning around and above the eyes