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35 Blog posts found

In the Lab

Targeting DNA Repair in Breast Cancer: PARP Inhibitors and Beyond

Scientists are looking to exploit defects in DNA repair as an Achilles’ heel in cancer.

A drawing of a DNA molecule with enzymes.

In the Clinic

Targeting Pancreatic Cancer: An Increased Focus on Developing New Clinical Trials

Pancreatic cancer is difficult to treat, but researchers are focused on developing treatments that are personalized based on each individual patient’s disease.

In the Lab

Communal Behavior within Cells Makes Cancers Easier to Target

Findings about proteins called molecular chaperones are shedding new light on possible approaches to cancer treatment.

Bees in a hive

In the Clinic

MSK’s New Fiona and Stanley Druckenmiller Center for Lung Cancer Research Takes on Biggest Cancer Killer

The new Fiona and Stanley Druckenmiller Center for Lung Cancer Research brings together MSK physicians and scientists in an intensive, multidisciplinary effort against the number-one cause of death from cancer in the nation.

Charles Rudin and David Jones, leaders of the Druckenmiller Center

In the Lab

Discovery Could Boost New Therapies for Myeloproliferative Neoplasms

Researchers have discovered a way to potentially make drugs more effective at treating certain blood cancers.

Illustration of normal blood cells (red discs) along with cancer cells (black spheres) floating through a blood vessel.

In the Lab

Manipulating a Single Gene Turns Colorectal Cancer Cells Back to Normal

For the first time, scientists have shown that the gene APC, which is mutated in the vast majority of colorectal cancers, might be a promising target for future therapies.

Organoid cell structures fluorescing in blue, green, and purple.

In the Lab

Uncharted Waters: The Making of a New Cancer Drug

A team of scientists is combining sophisticated chemistry and experiments in zebrafish to develop a new cancer drug that shows early potential against melanoma and metastatic breast cancer.

Portrait of a live zebrafish with dark patterning around and above the eyes

In the Lab

Miniature Device Could Unlock the Promise of Some Kidney Cancer Drugs

Memorial Sloan Kettering scientists have engineered a tiny particle that could ferry drugs directly to the kidneys and prevent their uptake in other organs.

Proximal tubule of the kidney.

Finding

Flanking Maneuver: Drug Combination Might Outsmart Resistant Head and Neck Cancers

Lab findings have suggested that a new combination of targeted therapies could be successful against certain head and neck cancers.

Investigator Maurizio Scaltriti

Decoder

What Are Exceptional Responders?

When a clinical trial of a new drug fails because most patients don’t respond, progress can still be made by analyzing the tumors of the rare patients who benefit.

Exceptional responders of new drugs in clinical trials.