Full TitleA Reduced Intensity Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients with Hematologic Malignancies Back to top
Cancers of the blood and bone marrow are treated with chemotherapy. Often treatment with chemotherapy alone is not successful for curing disease. Some patients are also offered a transplant with blood-forming stem cells from another person.
The traditional way of performing a donor transplant is to give high doses of chemotherapy and radiation therapy before giving stem cells. However, high doses of chemotherapy and radiation can have serious side effects. Doctors think a transplant would be safer and more likely to be successful using reduced doses of chemotherapy and radiation therapy.
The purpose of this study is to evaluate the effectiveness of a combination of chemotherapy and radiation therapy given at reduced doses followed by a cord blood transplant for treating patients with acute leukemia or myelodysplasia. The stem cells chosen for this transplant are from umbilical cord blood.Back to top
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have acute leukemia that is in complete first remission with a high risk of relapse or in complete second remission, OR have myelodysplastic syndrome that is determined to be poor risk.
- Patients who have previously received a transplant from a donor may not participate.
- Patients must be between the ages of 18 and 70.