Full TitleSafety and Efficacy Pilot Trial of the Anti-Viral and Anti-Tumor Activity of Velcade Combined with(R)ICE in Subjects with Relapsed/Refractory AIDS-Associated Non-Hodgkin’s Lymphoma (AMC Protocol #053) Back to top
The purpose of this study is to find the highest dose of a drug called bortezomib (Velcade) that can be given safely with a chemotherapy regimen called (R)ICE in patients with HIV-associated non-Hodgkin’s lymphoma that has returned or persisted despite treatment and contains the Epstein-Barr virus (EBV) and/or human herpes virus 8 (HHV-8).
Bortezomib is used to treat a cancer called multiple myeloma and certain types of lymphoma. (R)ICE includes the drugs ifosfamide, carboplatin, and etoposide, which may or may not be given with rituximab. The effect of bortezomib for reducing the amount of HIV in the blood will also be studied.Back to top
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have HIV-associated non-Hodgkin’s lymphoma that has returned or persisted despite treatment and contains EBV and/or HHV-8.
- At least 3 weeks must have passed since completion of prior chemotherapy and 2 weeks since completion of any radiation therapy and entry into the study, and patients must have recovered from any side effects.
- Patients must not be confined to a bed or chair for more than half of their normal waking hours.
- Patients must be age 18 or older.