Full TitleA Phase 1 Dose-Escalation Study of Intraperitoneal (IP) Cisplatin, IV/IP Paclitaxel, IV Bevacizumab, and Oral Olaparib for Newly Diagnosed Ovarian, Primary Peritoneal, and Fallopian Tube Cancer Back to top
Olaparib kills cancer cells by blocking the PARP protein, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more vulnerable to anticancer treatments. Olaparib is approved for treating some patients with ovarian cancer. It is taken orally (by mouth).
In this study, researchers want to identify the highest dose of olaparib that can be given safely in combination with other chemotherapy drugs in patients newly diagnosed with ovarian, fallopian tube, or primary peritoneal cancer. In addition to olaparib, patients will receive cisplatin (given intraperitoneally — into the abdomen through a port), paclitaxel (given intravenously or intraperitoneally), and bevacizumab (given intravenously).
Doctors also want to see if a patient’s BRCA mutation status affects the way they respond to treatment.Back to top
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have newly diagnosed ovarian, fallopian tube, or primary peritoneal cancer.
- Patients must have had their initial cancer surgery no more than 12 weeks before entering the study.
- Patients may not have previously received chemotherapy for their cancer, nor radiation therapy to the pelvis or prior treatment with bevacizumab or a PARP inhibitor.
- This study is for women age 18 and older.