Full TitlePhase II Trial of Carboplatin and Bevacizumab for the Treatment of Recurrent Low-grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma in Adults (CERN 09-02) Back to top
Ependymomas are tumors of the brain or spinal cord. Carboplatin is a drug commonly used to treat several types of cancer. Bevacizumab is a drug that works by inhibiting the growth of the blood vessels that tumors need to grow and spread. In this study, investigators are assessing the safety and effectiveness of combination therapy with carboplatin and bevacizumab in patients with ependymoma of the brain or spinal cord.
Bevacizumab is approved for treating gliomas and other cancers, but its use in combination with carboplatin in patients with ependymoma is considered investigational.Back to top
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have a confirmed diagnosis of intracranial or spinal ependymoma or anaplastic ependymoma that has continued to grow despite at least one regimen of chemotherapy.
- Patients must have recovered from the side effects of prior therapies. At least 4 weeks must have passed since completion of prior chemotherapy or major surgery and 6 weeks since any radiation therapy.
- Patients may have had prior carboplatin but not bevacizumab.
- Patients must be age 18 or older.