Full TitleAn Open-label, Phase II Study of Vemurafenib in Patients with BRAF V600 Mutation-Positive Cancers Back to top
Vemurafenib is approved for treating metastatic melanoma. It works by inhibiting the activity of BRAF, a protein which, when mutated, drives the growth of metastatic melanoma. Vemurafenib is approved specifically for adult patients with a BRAF mutation called V600. It is taken orally (by mouth).
In this study, researchers are assessing the effectiveness of vemurafenib for treating multiple myeloma and solid tumors other than melanoma which contain a BRAF V600 mutation, such as langerhans cell histiocytosis (LCH) and Erdheim-Chester Disease (ECD).Back to top
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have a solid tumor or multiple myeloma that is not responding to standard therapy or for which no standard therapy exists.
- Patients’ cancers must contain a BRAF V600 mutation.
- Patients must have recovered from the serious side effects of prior therapies before entering the study.
- Patients must be able to be ambulatory for more than half of their normal waking hours.
- Patients must be age 18 or older.