A Phase II Study of Inhaled Lipid Cisplatin in Pulmonary Recurrent Osteosarcoma

Full Title

Phase 2 Study of Inhaled Lipid Cisplatin in Pulmonary Recurrent Osteosarcoma Back to top

Purpose

Cisplatin is a drug commonly used to treat osteosarcoma (bone cancer). This study is assessing the safety and effectiveness of a form of the drug in which the cisplatin is combined with lipids (fatty substances) and inhaled by the patient using a nebulizer.

The investigators in this study are evaluating inhaled lipid-encapsulated cisplatin in adolescents and adults with recurrent osteosarcoma that had spread to the lungs and was surgically removed. It is hoped that this method of administering cisplatin will be more effective than conventional intravenous therapy for reaching any osteosarcoma cells remaining in the lungs after surgery.

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Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have osteosarcoma that spread to the lungs only.
  • Patients may have had up to two pulmonary recurrences and must have had the tumors removed surgically from the lungs.
  • Patients may have had up to two prior regimens of chemotherapy.
  • Patients must have recovered from the serious side effects of prior treatments. At least 2 weeks must have passed since completion of prior chemotherapy and no more than 4 weeks since prior lung surgery and entry into the study.
  • This study is open to patients ages 13 and older.

For more information and to inquire about eligibility for this study, please contact Dr. Alexander Chou at 212-639-6057.

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Protocol

12-205

Phase

II

Disease Status

Relapsed or Refractory

Investigator

Co-Investigators

Locations