A Phase II Study of a Pediatric-Inspired Combination Chemotherapy Regimen in Adults with Acute Lymphoblastic Leukemia

Full Title

A Novel “Pediatric-Inspired” Regimen with Reduced Myelosuppressive Drugs for Adults (aged 18-60) with Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia


There is no standard chemotherapy regimen for treating adults with acute lymphoblastic leukemia (ALL), in terms of which drugs to give and how to give them. Children with ALL tend to respond better to chemotherapy than adults with this disease. The purpose of this study is to determine if the chemotherapy drugs used to treat children with ALL can be used safely and effectively in adults with previously untreated ALL.

Patients in this study will receive different anticancer drugs during different phases over several months. All of the drugs are FDA-approved for treating leukemia.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have a confirmed diagnosis of Ph-negative previously untreated ALL.
  • Patients must be able to be ambulatory for more than half of their normal waking hours.
  • This study is open to patients ages 18 to 60.

For more information about this study and to inquire about eligibility, please contact Dr. Jae Park at 212-639-4048.