A Phase II Study of Dose-Adjusted EPOCH Chemotherapy with or without Rituximab in Patients with Untreated Burkitt Lymphoma, Diffuse Large B-Cell Lymphoma, or Plasmablastic Lymphoma

Full Title

Phase II Study of Dose-Adjusted EPOCH+/- Rituximab in Adults With Untreated Burkitt Lymphoma, C-Myc Positive Diffuse Large B-Cell Lymphoma and Plasmablastic Lymphoma (NCI #9177; AMC #086)


Many of the standard treatments for Burkitt lymphoma and other types of aggressive lymphomas cause serious side effects that require long stays in the hospital. An investigational approach called “dose-adjusted” EPOCH with or without rituximab (R) has been developed for treating these cancers and does not appear to cause the same severity of side effects or require long hospital stays. With dose-adjusted therapy, the doctor monitors the patient’s blood counts and side effects and adjusts the doses of the drugs accordingly during each cycle of therapy.

The purpose of this study is to evaluate the safety and effectiveness of dose-adjusted EPOCH with and without rituximab in patients with untreated Burkitt lymphoma, DLBCL, or plasmablastic lymphoma. EPOCH includes the drugs etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin. Rituximab is a standard drug used to treat lymphoma. Patients in this study will receive dose-adjusted EPOCH with or without rituximab of varying doses and cycles depending on the aggressiveness and type of their lymphoma.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • This study is open to patients with previously untreated Burkitt lymphoma, c-MYC-positive DLBCL, or plasmablastic lymphoma.
  • Patients must be age 18 or older.

For more information about this study and to inquire about eligibility, please contact Dr. Ariela Noy at 212-639-7423.