Full TitleA Phase I Trial of SGN-CD33A in Patients with CD33-positive Acute Myeloid Leukemia Back to top
The purpose of this study is to identify the highest dose of an investigational drug called SGN-CD33A that can be given safely in patients with acute myeloid leukemia (AML) that has persisted or returned despite standard therapy, or is not being treated with high-dose induction chemotherapy. SGN-CD33A has two parts: one (an antibody) that attaches to a protein called CD33 on the surface of cancer cells (including AML) and another (an anticancer drug) that kills the cancer. SGN-CD33A is given intravenously (by vein).Back to top
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have AML that has returned despite prior therapy, or patients must have declined high-dose induction chemotherapy for AML and have received no more than one previous regimen of palliative therapy.
- At least 2 weeks must have passed since completion of prior non-myeloablative treatment (therapy which does not destroy blood-forming cells) and 4 weeks since myeloablative therapy (high-dose induction/consolidation chemotherapy) and entry into the study.
- Patients who previously had a stem cell transplant may not participate.
- This study is open to patients age 18 and older.