Full TitleA Phase 1b/2 Study of Ramucirumab in Combination with LY2875358 in Patients with Advanced Cancer Back to top
LY2875358 is an investigational drug designed to inhibit cancer growth by blocking the activity of a protein called MET, which some cancer cells need to grow. Ramucirumab is an anticancer drug approved to treat cancer of the stomach, cancer of the junction between the esophagus and the stomach, and non-small cell lung cancer. It inhibits the growth of the blood vessels that tumors need to grow and spread by blocking the activity of a protein called VEGFR2.
In this study, researchers want to find the highest dose of LY2875358 that can be given safely with ramucirumab in patients with advanced solid cancers that are no longer responding to standard treatments. Both drugs are given intravenously (by vein).Back to top
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have an advanced solid cancer which is no longer responding to standard therapies.
- Patients must have recovered from the serious side effects of previous treatments before entering the study.
- Patients must be able to be walk and do routine activities for more than half of their normal waking hours.
- This study is open to patients age 18 and older.