A Phase III Study of Preoperative Radiotherapy plus Surgery versus Surgery Alone for Patients with Retroperitoneal Sarcoma

Full Title

A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients with Retroperitoneal Sarcoma (RPS) (STRASS) (EORTC protocol 62092-22092)


Surgery is the usual treatment for retroperitoneal sarcomas that can be removed. However, in some patients, the cancer comes back. In this study, researchers want to see if giving radiation therapy before surgery is better than surgery alone for reducing the risk of cancer recurrence and to see if radiation can shrink the tumor before surgery. They will also be comparing the side effects of radiation therapy plus surgery with surgery alone.

Patients in this study will be randomly assigned to receive radiation therapy (five days a week for six to seven weeks) followed by surgery, or surgery alone. The two groups will then be compared with regard to treatment effectiveness and side effects.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have retroperitoneal sarcoma that has not yet been treated, has not metastasized (spread to other organs), and is able to be surgically removed.
  • This study is for patients age 18 and older.

For more information about this study and to inquire about eligibility, please contact Dr. Aimee Crago at 212-639-4807.