A Phase II Study of CMV-Immune T cells from a Third Party for the Treatment of Cytomegalovirus Infection after Allogeneic Stem Cell Transplantation

Full Title

A Phase II Trial of Third Party Donor Derived CMVpp65 specific T-cells for The Treatment of CMV Infection or Persistent CMV Viremia after Allogeneic Hematopoietic Stem Cell Transplantation

Purpose

Cytomegalovirus (CMV) is a potential complication after stem cell transplantation. There are drugs used to treat CMV, but in some patients the virus has become resistant to these drugs, or the patient cannot tolerate them. In these cases, giving infusions of T cells (infection-fighting white blood cells) that are immune to CMV may be a potentially effective treatment.

In this study, researchers are evaluating the effectiveness of giving CMV-immune T cells from a “third party” to patients with persistent CMV infection after transplantation of stem cells from a donor. Third-party donors are used for patients whose donors don’t have CMV-immune stem cells or when the donor is not available. The T cells are donated by another person , a third party who is partially matched to the patient’s tissue type and whose T cells are immune to CMV. The immuneT cells contributed by the third-party donor are grown and selected in the laboratory for their ability to kill CMV infected cells.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have CMV infection after allogeneic stem cell transplantation which is not responding despite more than two weeks of conventional CMV treatment.
  • This study is for patients whose donors don’t have CMV-immune stem cells or whose donors are not available.
  • Patients of all ages are eligible to participate.

For more information about this study and to inquire about eligibility, please contact Dr. Susan Prockop at 212-639-6715.

Protocol

14-070

Phase

II

Investigator

Co-Investigators

Locations