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A Phase II Study of Whole-Lung IMRT in Children and Adults with Synovial Sarcoma that Spread to the Lungs

Full Title

Whole Lung IMRT in Children and Adults with Synovial Sarcoma and Lung Metastases


The standard treatment for synovial sarcoma that has spread to the lungs is chemotherapy with or without surgery to remove the lung tumors. However, the cancer often comes back. Since synovial sarcoma is known to be sensitive to radiation therapy, doctors want to see if adding whole-lung radiation therapy to chemotherapy/surgery can reduce the chance that the tumors will grow again.

In this study, researchers want to determine if it is feasible to use intensity-modulated radiation therapy (IMRT) to the entire lungs in children and adults with synovial sarcoma that has spread to the lungs. IMRT is a highly focused form of radiation therapy in which radiation beams of customized shapes and intensities are precisely directed to a patient’s tumors, thereby delivering less radiation to nearby organs such as the heart.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have been diagnosed with lung metastases from synovial sarcoma that either are no longer present on a CT scan after chemotherapy or are less than 1 cm in size.
  • This study is for patients age 1 year and older.
  • Patients may not have previously received radiation therapy to the chest.

For more information about this study and to inquire about eligibility, please contact Dr. Suzanne Wolden at 212-639-5148.