Full TitleLocal Control with Reduced-dose Radiotherapy for High-Risk Neuroblastoma
Radiation therapy is commonly used to treat patients with high-risk neuroblastoma after surgery, to kill any remaining cancer cells and to reduce the risk of the cancer coming back. While the radiation dose currently used in these patients is effective, it can cause long-term side effects. The purpose of this study is to see if using a lower dose of radiation in these patients can still be effective while causing fewer side effects.
Patients in this study will receive intensity-modulated radiation therapy or proton beam radiotherapy after surgery to maximize the delivery of radiation to tumor tissue while minimizing exposure to healthy tissues.
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have high-risk neuroblastoma that was already treated with chemotherapy and surgery.
- Patients may not have already received radiation therapy.
- This study is for patients aged 1 to 18 years.