A Study Assessing the Influence of Breast MRI Before Lumpectomy on Outcomes, Quality of Life, and Costs in Women with Breast Cancer

Full Title

Effect of Preoperative Breast MRI on Surgical Outcomes, Costs and Quality of Life of Women with Breast Cancer (Alliance A011104 / ACRIN 6694)

Purpose

Mammography and sometimes ultrasound are typically used before breast cancer surgery to provide the surgeon with information to plan the operation. In this study, researchers want to learn if adding breast magnetic resonance imaging (MRI) before surgery affects how well patients do after the surgery, as well as its influence on a woman’s quality of life and on medical costs.

Patients in this study include those undergoing breast-conserving surgery (lumpectomy). Women will be randomly assigned to have breast MRI before surgery or no MRI before surgery. They will also complete quality of life questionnaires after the operation.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must be women with stage I or II breast cancer that is either positive for the HER2 receptor, or negative for estrogen and progesterone receptors and HER2 (“triple-negative breast cancer”).
  • Patients must be candidates for breast-conserving surgery.
  • Patients may not have already received other breast cancer therapies before the surgery.
  • Patients with BRCA genetic mutations and those with cancer in both breasts may not participate.
  • Patients should be able to undergo MRI. For example, those with many types of metal implants or implanted medical devices (such as pacemakers) may not undergo MRI.
  • This study is for patients age 18 and older.

For more information about this study and to inquire about eligibility, please contact Dr. Andrea Barrio at 646-888-5118.

Protocol

14-198

Phase

III

Disease Status

Newly Diagnosed

Investigator

Co-Investigators