Examining Gut Bacteria in People with Lynch Syndrome and Hereditary Colonic Polyposis Syndromes

Full Title

Metagenomic Evaluation of the Gut Microbiome in Patients with Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes

Purpose

Changes in gut bacteria have been associated with an increased risk of colorectal cancer, but the nature of this relationship is not well understood. In this study, researchers want to learn more about the role that bacteria in the gut have on colorectal cancer development in individuals with Lynch syndrome or other polyposis syndromes.

Researchers will be collecting stool specimens as well as additional colon tissue samples during scheduled colonoscopies at Memorial Sloan Kettering in people with Lynch syndrome and other hereditary colonic polyposis syndromes. Participants will also complete a questionnaire about their diet and lifestyle. The samples collected will be used to study the effect of diet on naturally occurring bacteria in the gut and their impact on health, including the risk of colorectal cancer.

Eligibility

Participants in this study include people age 18 and older with Lynch syndrome or other colonic polyposis syndromes who are receiving routine colonoscopy at Memorial Sloan Kettering.

For more information about this study, please contact Dr. Zsofia Stadler at 646-888-4039 or Annie Lincoln, MS, at 646-888-4083.

Protocol

15-016

Investigator

Co-Investigators

Locations