A Study Assessing the Effects of Aerobic Exercise Amount and Intensity in Postmenopausal Women at High Risk for Breast Cancer


Full Title

Dose-Response of Aerobic Training in Women at High-Risk for Development of Breast Cancer


Prior studies have shown that high levels of exercise may reduce breast cancer risk, but what has not been known is the best intensity and amount of exercise required to be protective. Nor is it known how exercise reduces breast cancer risk. In this study, researchers want to determine the optimal amount of exercise needed to change certain factors associated with breast cancer risk.

Participants in this study will be postmenopausal women who have an elevated risk of breast cancer. Women will need to have a needle biopsy of breast tissue for analysis, as well as body composition assessment, blood tests, and other tests. They will then be randomly assigned to one of four groups:

  1. Walking on a treadmill three times a week for a total of 75 minutes

  2. Walking on a treadmill three times a week for a total of 150 minutes

  3. Walking on a treadmill five times a week for a total of 300 minutes

  4. No exercise during the study period (but these women will be “wait-listed” to start 150 minutes of weekly exercise training after the study period)

At the end of the six-month study period, women will have the breast needle biopsy and the other tests they had at the beginning of the study repeated, and the results of the two sets of tests will be compared to evaluate the effects of exercise.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Participants must be postmenopausal women who have a high risk of breast cancer due to a personal or family medical history or genetic mutations.
  • Women may not have previously been diagnosed with invasive cancer or ductal carcinoma in situ.
  • Participants must be sedentary upon entering the study (performing less than 75 minutes of moderate or vigorous exercise each week).

For more information about this study and to inquire about eligibility, please contact Dr. Lee Jones at 646-888-8102.







Jones, Lee, PhD